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High blood pressure and hypertension in children with newly diagnosed acute leukemia and lymphoma

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Abstract

Little has been published on the rate of prehypertension (HBP) and hypertension (HTN) in children with hematologic malignancies. This study was preformed to determine the prevalence and predictors of HBP and HTN in newly diagnosed acute leukemia and lymphoma patients. Retrospectively, blood pressure (BP) values were followed from admission until normalization in 102 children. HBP and HTN were defined as either a systolic or diastolic value ≥ the 90th and 95th percentile BP measurement, respectively. HBP and HTN were identified in 68.6% and 52.9% of children prior to chemotherapy and 78.4% and 67.3% postchemotherapy, respectively. Mean time to BP normalization was 54days. Only ten children (15% of HTN patients) received antihypertensive therapy. Logistic regression determined that the only predictor for HBP and HTN was the estimated glomerular filtration rate (eGFR) at the time of admission—every 10ml/min per 1.73m2 increase led to a 16% and 14% decrease in the odds of postchemotherapy HBP (p = 0.02) and HTN (p = 0.03), respectively. A surprisingly high prevalence of BP abnormalities was identified and lower eGFR predicted HBP and HTN in children with newly diagnosed hematologic malignancies. Better recognition and serious consideration for treatment should be given to this cardiovascular abnormality.

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Acknowledgements

This study was funded by a Children’s Miracle Network Resident Scholar Award to Dr. Chrystal Louis.

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Authors and Affiliations

  1. Texas Children’s Cancer Center, Texas Children’s Hospital, Houston, TX, USA

    Chrystal U. Louis

  2. Department of Pediatrics, Section of Pediatric Nephrology, University of California Davis Children’s Hospital, Sacramento, CA, USA

    Lavjay Butani

  3. Texas Children’s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3-3320, Houston, TX, 77030, USA

    Chrystal U. Louis

Authors
  1. Chrystal U. Louis
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  2. Lavjay Butani
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Corresponding author

Correspondence to Chrystal U. Louis.

Additional information

This study was submitted in abstract form and presented as a poster presentation at the American Society of Nephrology Meeting in St. Louis, Mo, USA, in 2004 (abstract number F-PO630).

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Louis, C.U., Butani, L. High blood pressure and hypertension in children with newly diagnosed acute leukemia and lymphoma. Pediatr Nephrol 23, 603–609 (2008). https://doi.org/10.1007/s00467-007-0720-y

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  • DOI: https://doi.org/10.1007/s00467-007-0720-y

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