Skip to main content
SpringerLink
Log in

C1q nephropathy in a child with a chromosome 13 deletion

  • Brief Report
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

C1q nephropathy (C1qNP) is a rare cause of childhood nephrotic syndrome (NS). We describe a child with retinoblastoma, lipomyelomeningocele and a chromosome 13 deletion who presented with massive proteinuria due to C1qNP. Despite steroid resistance, successful treatment of the NS was achieved with mycophenolate mofetil.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Jones E, Magil A (1982) Nonsystemic mesangiopathic glomerulonephritis with “full-house” immunofluorescence. Pathological and clinical observations in five patients. Am J Clin Pathol 78:29–34

    Article  CAS  Google Scholar 

  2. Jennette JC, Hipp CG (1985) C1q Nephropathy: A distinct pathologic entity usually causing nephritic syndrome. Am J Kidney Dis 6:103–110

    Article  CAS  Google Scholar 

  3. Markowitz GS, Schwimmer JA, Stokes MB, Nasr S, Seigle RL, Valeri AM, D’Agati VD (2003) C1q nephropathy: a variant of focal segmental glomerulosclerosis. Kidney Int 64:1232–1240

    Article  CAS  Google Scholar 

  4. Iskandar SS, Browing MC, Lorentz WB (1991) C1q nephropathy: a pediatric clinicopathologic study. Am J Kidney Dis 18:459–465

    Article  CAS  Google Scholar 

  5. Davenport A, Maciver AG, Mackenzie JC (1992) C1Q nephropathy: do C1q deposits have any prognostic significance in the nephrotic syndrome? Nephrol Dial Transpl 7:391–396

    Article  CAS  Google Scholar 

  6. Nishida M, Kawakatsu H, Komatsu H, Ishiwari K, Tamai M, Sawada T (2000) Spontaneous Improvement in a case of C1q nephropathy. Am J Kidney Dis 35:1–6

    Article  Google Scholar 

  7. Gencik A, Auf der Maur P, Gencikova A, Lutschg J (1982) Retinoblastoma and chromosome 13 deletion. Helv Paediatr Acta 37:457–464

    CAS  PubMed  Google Scholar 

  8. Pollak MR (2002) Inherited podocytopathies: FSGS and nephrotic syndrome from a genetic viewpoint. J Am Soc Nephrol 13:3016–3023

    Article  Google Scholar 

  9. Vats AN, Ishwad C, Vats KR, Moritz M, Ellis D, Mueller C, Surti U, Parizhskaya M, Meza MP, Burke L, Schneck FX, Saxena M, Ferrell R (2003) Steroid-resistant nephrotic syndrome and congenital anomalies of kidneys: evidence of locus on chromosome 13q. Kidney Int 64:17–24

    Article  CAS  Google Scholar 

  10. Srivastava T, Taboada EM, Alon US (2000) C1q nephropathy presenting as rapidly progressive crescentic glomerulonephritis. Pediatr Nephrol 14:976–979

    Article  CAS  Google Scholar 

  11. Byrne J, Fears TR, Whitney C, Parry DM (1995) Survival after retinoblastoma: long-term consequences and family history of cancer. Med Pediatr Oncol 24:160–165

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pediatric Nephrology and Transplantation, East Wing, Suite 304, Saint Barnabas Medical Center, 94 Old Short Hills Road , Livingston, NJ, 07039, USA

    Isabel Roberti

  2. Department of Pediatrics, Newark Beth Israel Medical Center, Newark, NJ, USA

    Sachin Sachdev & Adam Aronsky

  3. Department of Pathology, Saint Barnabas Medical Center, Livingston, NJ, USA

    Dae Un Kim

Authors
  1. Isabel Roberti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sachin Sachdev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Adam Aronsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dae Un Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Isabel Roberti.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roberti, I., Sachdev, S., Aronsky, A. et al. C1q nephropathy in a child with a chromosome 13 deletion. Pediatr Nephrol 21, 737–739 (2006). https://doi.org/10.1007/s00467-006-0046-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-006-0046-1

Keywords

Search

Navigation