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“Why do they do that?”

The compliance conundrum

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Abstract

The problem of compliance or adherence with medical advice is complex in every aspect. Frequently compliance definitions vary, measurements are not well quantified, interventions are uncontrolled or not fully elaborated. Nevertheless the importance of facilitating and maximizing compliance is undeniable. As the medications available become more potent and effective, the challenge of achieving optimal medication compliance comes into sharper focus and becomes a concern for everyone involved in health care. Here some of the recent clinical research on compliance is presented together with strategies intended to improve medication compliance by pediatric patients.

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References

  1. Haynes RB, Taylor DW, Sackett DL (1979) Compliance in health care. Johns Hopkins University Press, Baltimore, MD, pp 1–2

  2. WHO (2003) Adherence to long-term therapy: evidence for action. WHO, Geneva (see http://www.who.int/chronic_conditions/adherencereport)

  3. Haynes RB, McDonald H, Garg AX, Montague P (2004) Interventions for helping patients to follow prescriptions for medications. The Cochrane Database of Systematic Reviews, Volume 3. Wiley, Hoboken, NJ

  4. Matsui DM (1997) New frontiers in pediatric drug therapy. Pediatr Clin North Am 44:1–14

    CAS  PubMed  Google Scholar 

  5. DiMatteo (2004) Variations in patients’ adherence to medical recommendations—a quantitative review of 50 years of research. Med Care 42:200–209

    Article  PubMed  Google Scholar 

  6. Cramer JA (2004) A systematic review of adherence with medications for diabetes. Diabetes Care 27:1218–1224

    PubMed  Google Scholar 

  7. McDonald HP, Garg AX, Haynes RB (2002) Interventions to enhance patient adherence to medication prescriptions. JAMA 288:2868–2879

    Article  PubMed  Google Scholar 

  8. Lang JM, Buring JE, Rosner B, Cook N, Hennekens CH (1991) Estimating the effect of the run-in on the power of the physicians’ health study. Stat Med 10:1585–1593

    CAS  PubMed  Google Scholar 

  9. Hennekens CH, Eberlein KA (1985) A randomized trial of aspirin and beta-carotene among U.S. physicians. Prev Med 14:165–168

    Article  CAS  PubMed  Google Scholar 

  10. Loghman-Adham M (2003) Medication noncompliance in patients with chronic disease: issues in dialysis and renal transplantation. Am J Manag Care 9:155–171

    PubMed  Google Scholar 

  11. Laederach-Hofmann K, Bunzel B (2000) Noncompliance in organ transplant recipients: a literature review. Gen Hosp Psychiat 22:412–424

    Article  CAS  Google Scholar 

  12. Griffin KJ, Elkin TD (2001) Non-adherence in pediatric transplantation: a review of the existing literature. Pediatr Transplant 5:246–249

    Article  CAS  PubMed  Google Scholar 

  13. Vrijens B, Urquhart J (2005) Patient adherence to prescribed anti-microbial drug dosing regimens. J Antimicrob Chemother 55:616–627

    Article  CAS  PubMed  Google Scholar 

  14. Shemesh E (2004) Non-adherence to medications following pediatric liver transplantation. Pediatr Transplant 8:600–605

    Article  PubMed  Google Scholar 

  15. Dobbels F, De Geest S, Van Cleemput J, Droogne W, Vanhaecke J (2004) Effect of late medication non-compliance on outcome after heart transplantation: a 5-year follow-up. J Heart Lung Transplant 23:1245–1251

    Article  PubMed  Google Scholar 

  16. Nevins TE, Kruse L, Skeans MA, Thomas W (2001) The natural history of azathioprine compliance after renal transplantation. Kidney Int 60:1565–1570

    Article  CAS  PubMed  Google Scholar 

  17. Penkower L, Dew MA, Ellis D, Sereika SM, Kitutu JMM, Shapiro R (2003) Psychological distress and adherence to the medical regimen among adolescent renal transplant recipients. Am J Transplant 3:1418–1425

    Article  PubMed  Google Scholar 

  18. Korsch B, Fine RN, Negrete VF (1978) Noncompliance in children with renal transplants. Pediatrics 61:872–876

    CAS  PubMed  Google Scholar 

  19. Schneider J, Kaplan SH, Greenfield S, Li W, Wilson IB (2004) Better physician-patient relationships are associated with higher reported adherence to antiretroviral therapy in patients with HIV infection. J Gen Intern Med 19:1096–1103

    Article  PubMed  Google Scholar 

  20. Claxton AJ, Cramer J, Pierce C (2001) A systematic review of the associations between dose regimens and medication compliance. Clin Therapeutics 23:1296–1310

    Google Scholar 

  21. Urquhart J (1995) Correlates of variable patient compliance in drug trials: relevance in the new health care environment. Adv Drug Res 26:238–249

    Google Scholar 

  22. Rigsby MO, Rosen MI, Beauvais JE, Cramer JA, et al (2000) Cue-dose training with monetary reinforcement—pilot study of an antiretroviral adherence intervention. J Gen Intern Med 15:841–847

    Article  CAS  PubMed  Google Scholar 

  23. Rosen MI, Rigsby MO, Salahi JT, Ryan CE, Cramer JA. (2004) Electronic monitoring and counseling to improve medication adherence. Behav Res Ther 42:409–422

    Article  PubMed  Google Scholar 

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Acknowledgements

The author is particularly grateful to Dr. William Robiner for many stimulating discussions and his useful suggestions. This work was supported by a grant from the NIH (PO1 DK-13083).

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Correspondence to Thomas E. Nevins.

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Nevins, T.E. “Why do they do that?”. Pediatr Nephrol 20, 845–848 (2005). https://doi.org/10.1007/s00467-005-1926-5

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  • DOI: https://doi.org/10.1007/s00467-005-1926-5

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