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Impact of inflammation and oxidative stress on vascular calcifications in chronic kidney disease

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Abstract

Vascular and/or valvular calcifications in patients with chronic kidney disease (CKD) appear to indicate a poor prognosis in terms of overall survival and cardiovascular morbidity and mortality. Inflammation and oxidative stress represent new features of the arterial and/or valvular calcification process. However, only limited observational and epidemiological data are available in these areas. Therefore, the link between inflammation, oxidation and vascular and/or valvular calcifications deserves careful consideration in CKD patients, since they may become targets for the development of new therapeutic strategies.

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Author information

Authors and Affiliations

  1. EA2087, Amiens University Hospital, UPJV, Amiens, France

    Z. A. Massy, C. Mazière, C. Tribouilloy, M. Slama, M. Andrejak & J. C. Mazière

  2. EA 2086, Amiens University Hospital, UPJV, Amiens, France

    S. Kamel, M. Brazier & G. Choukroun

Authors
  1. Z. A. Massy
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  2. C. Mazière
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  3. S. Kamel
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  4. M. Brazier
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  5. G. Choukroun
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  6. C. Tribouilloy
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  7. M. Slama
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  8. M. Andrejak
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  9. J. C. Mazière
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Correspondence to Z. A. Massy.

Additional information

This work was presented in part at the IPNA Seventh Symposium on Growth and Development in Children with Chronic Kidney Disease: The Molecular Basis of Skeletal Growth, 1–3 April 2004, Heidelberg, Germany

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Massy, Z.A., Mazière, C., Kamel, S. et al. Impact of inflammation and oxidative stress on vascular calcifications in chronic kidney disease. Pediatr Nephrol 20, 380–382 (2005). https://doi.org/10.1007/s00467-004-1623-9

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  • DOI: https://doi.org/10.1007/s00467-004-1623-9

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