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Interstitial nephritis from mesalazine: case report and literature review

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Abstract

We report a new case of biopsy-confirmed mesalazine-induced interstitial nephritis in an 18-year-old male with ulcerative colitis. His renal function improved with drug discontinuation and corticosteroid treatment. An English literature review revealed an additional 22 cases of this complication that, taken together, showed (1) a male predominance, (2) an absence of specific symptoms or findings on urinalysis, (3) a 61% frequency of residual chronic renal insufficiency with 13% of patients developing end-stage renal disease, and (4) an apparent favorable response to steroid therapy. We conclude that patients receiving 5-aminosalicylates should be routinely monitored with serum creatinine measurements to prevent this uncommon but potentially serious adverse drug reaction.

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Authors and Affiliations

  1. Department of Pathology, University of Rochester School of Medicine, New York, USA

    Lois J. Arend

  2. Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, New York, USA

    James E. Springate

  3. Division of Nephrology, Women’s and Children’s Hospital of Buffalo, 219 Bryant Street, Buffalo, New York 14222, USA

    James E. Springate

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  1. Lois J. Arend
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  2. James E. Springate
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Correspondence to James E. Springate.

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Arend, L.J., Springate, J.E. Interstitial nephritis from mesalazine: case report and literature review. Pediatr Nephrol 19, 550–553 (2004). https://doi.org/10.1007/s00467-004-1411-6

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  • DOI: https://doi.org/10.1007/s00467-004-1411-6

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