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Nephrogenic fibrosing dermopathy in pediatric patients

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Abstract

Nephrogenic fibrosing dermopathy (NFD) is a rare and recently recognized sclerosing skin disorder of unknown etiology. Reported cases have occurred in patients with chronic renal failure, with or without renal replacement therapy. All previous cases have been reported in older adult patients. We describe two pediatric patients who recently developed this condition and review the existing literature for NFD. Our patients included an 8-year-old boy on peritoneal dialysis with no prior renal transplant and a 19-year-old boy on hemodialysis with a history of previous failed renal transplants. We speculate that the recent emergence of this condition and occurrence in patients with chronic renal failure suggest an association with some newer pharmacological agent that has recently come into wide use. Since both our patients also had previously experienced large vessel thrombosis, hypercoagulable states may also be implicated.

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Acknowledgements

The authors thank Dr. Shawn Cowper for useful discussions regarding our patients. This work was presented in abstract form at the 40th annual meeting of the American Society of Dermatopathology in October 2003.

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Authors and Affiliations

  1. Division of Dermatology, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA

    Sima M. Jain, Stanton Wesson, Erica Canova & Miranda Hoy

  2. Department of Pathology, University of Florida College of Medicine, Gainesville, Florida, USA

    Ashraf Hassanein

  3. Division of Pediatric Nephrology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA

    Robert S. Fennell & Vikas R. Dharnidharka

  4. Division of Pediatric Nephrology, University of Florida Health Science Center, PO Box 100296, Gainesville, FL 32610–0296, USA

    Vikas R. Dharnidharka

Authors
  1. Sima M. Jain
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  2. Stanton Wesson
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  3. Ashraf Hassanein
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  4. Erica Canova
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  5. Miranda Hoy
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  6. Robert S. Fennell
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  7. Vikas R. Dharnidharka
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Corresponding author

Correspondence to Vikas R. Dharnidharka.

Additional information

Sima M. Jain and Stanton Wesson contributed equally to this report

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Jain, S.M., Wesson, S., Hassanein, A. et al. Nephrogenic fibrosing dermopathy in pediatric patients. Pediatr Nephrol 19, 467–470 (2004). https://doi.org/10.1007/s00467-003-1380-1

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  • DOI: https://doi.org/10.1007/s00467-003-1380-1

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