Skip to main content

Advertisement

SpringerLink
Log in

Antibody response to influenza A vaccination in children with nephrotic syndrome

  • Original Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

The aim of this study was to determine the antibody response to influenza vaccination in children with nephrotic syndrome (NS). Nineteen children with NS and 10 healthy controls were vaccinated with a 1999–2000 influenza vaccine. A dose of 0.25 ml was used for those under 6 years and 0.5 ml for those over 6 years. All children were given two doses with a month between each dose. Antibody titers were measured before vaccination and 1 month after vaccination in both groups and 6 months after vaccination in 8 patients with NS. The proportion of subjects in the nephrotic group with protective antibody titers before immunization (10.5%) was significantly lower than the proportion at 1 (78.9%) and 6 months (87.5%) post vaccination. The mean concentration of specific IgG antibodies to influenza A in the NS group increased 6-fold at 1 month and approximately 14-fold at 6 months. These results suggest that pediatric patients with NS have an adequate antibody response to influenza A vaccine. Protective antibody titers to influenza A were maintained at 6 months after immunization in 8 patients with NS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ljungman P, Andersson J, Aschan J, Barkholt L, Ehrnst A, Johansson M, Weiland O (1993) Influenza A in immunocompromised patients. Clin Infect Dis 17:244–247

    CAS  PubMed  Google Scholar 

  2. Steele RW (1994) Current status of vaccines and immune globulins for children with renal disease. Pediatr Nephrol 8:7–10

    PubMed  Google Scholar 

  3. Beyer WEP, Noordzij TC, Kramer P, Diderich PP, Op den Hoek CT, Janssen J, Masurel N, Weimar W (1990) Effect of immunomodulator thymopentin on impaired seroresponse to influenza vaccine in patients on haemodialysis. Nephron 54:296–301

    CAS  PubMed  Google Scholar 

  4. Jukka N, Pretti V, Jorma F, Antero K (1983) Influenza vaccination in patients with chronic renal failure. Scand J Infect Dis 14:245–251

    Google Scholar 

  5. American Academy of Pediatrics (1997) Immunization in special circumstances. In: Peter G (ed) : report of the Committee on Infectious Diseases, 24th edn. American Academy of Pediatrics, Grove Village, Ill., pp 58–59

  6. Fivush BA, Neu AM (1998) Immunization guidelines for pediatric renal disease. Semin Nephrol 18:256–263

    CAS  PubMed  Google Scholar 

  7. Brydak LB, Machala M (2000) Humoral immune response to influenza vaccination in patients from high risk groups. Drugs 60:35–53

    CAS  PubMed  Google Scholar 

  8. Schnaper HW (1989) The immune system in minimal change nephrotic syndrome. Pediatr Nephrol 3:101–110

    CAS  PubMed  Google Scholar 

  9. Brydak LB, Rajkowski T, Machala M, Weglarska J, Sieniawska M (1998) Humoral antibody response following influenza vaccination in patients with nephrotic syndrome. Antiinfect Drugs Chemother 16:151–155

    CAS  Google Scholar 

  10. MacDonald NE, Wolfish N, McLaine P, Phipps P, Rossier E (1986) Role of respiratory viruses in exacerbations of primary nephrotic syndrome. J Pediatr 108:378–382

    CAS  PubMed  Google Scholar 

  11. Suga T, Niki H, Niikura M, Matsumoto Y, Nishimura T, Nakajima K, Miyazaki M, Endoh M, Nomoto Y, Sakai H (1990) Influenza antibody titers after vaccination of chronic renal failure patients, before and during hemodialysis, or on chronic ambulatory peritoneal dialysis. Tokai J Exp Clin Med 15:245–251

    CAS  PubMed  Google Scholar 

  12. Cappel R, Van Beers D, Liesnard C, Dratwa M (1983) Impaired humoral and cell-mediated immune responses in dialysed patients after influenza vaccination. Nephron 33:21–25

    CAS  PubMed  Google Scholar 

  13. Sheht KJ, Sedmak GV, Freeman ME, Eisenberg C (1979) Hemagglutination-inhibiting antibodies in vaccinated children with renal disease. JAMA 242:1752–1754

    PubMed  Google Scholar 

  14. Furth SL, Neu AM, McColley SA, Case B, Steinhoff M, Fivush B (1995) Immune response to influenza vaccination in children with renal disease. Pediatr Nephrol 9:566–568

    CAS  PubMed  Google Scholar 

  15. Nichol KL (1993) Vaccines and the elderly. Immunol Allergy Clin North Am 3:673–693

    Google Scholar 

  16. Kielstein JT, Termuhlen L, Sohn J, Kliem V (2000) Minimal change nephrotic syndrome in a 65-year-old patient following influenza vaccination. Clin Nephrol 54:246–248

    CAS  PubMed  Google Scholar 

  17. Işlek I, Cengiz K, Cakir M, Kuçukoduk S (2000) Nephrotic syndrome following hepatitis B vaccination. Pediatr Nephrol 14:89–90

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Nephrology, Medical Faculty, Erciyes University, 38039 Kayseri, Turkey

    Hakan M. Poyrazoğlu, Ruhan Düşünsel, Zübeyde Gündüz & Selmin Köklü

  2. Department of Immunology, Medical Faculty, Erciyes University, Kayseri, Turkey

    Türkan Patiroğlu

Authors
  1. Hakan M. Poyrazoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ruhan Düşünsel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zübeyde Gündüz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Türkan Patiroğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Selmin Köklü
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hakan M. Poyrazoğlu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Poyrazoğlu, H.M., Düşünsel, R., Gündüz, Z. et al. Antibody response to influenza A vaccination in children with nephrotic syndrome. Pediatr Nephrol 19, 57–60 (2004). https://doi.org/10.1007/s00467-003-1301-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-003-1301-3

Keywords

Search

Navigation