Skip to main content
SpringerLink
Log in

Incidence of pediatric IgA nephropathy

  • Original Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

Immunoglobulin A (IgA) nephropathy progresses without apparent signs. The only available means of knowing the precise incidence of this disease in children is to analyze data from the school urinary screening system. Students between 6 and 15 years old with IgA nephropathy detected by school urinary screening from 1983 to 1999 in Yonago City, Japan, were examined. In addition, two hospitals with pediatric care units administered a questionnaire and patients with pediatric IgA nephropathy detected by means other than the school urinary screening program were recruited. Of 270,902 children examined by the school urinary screening system, 29 demonstrated suspected chronic nephritis on the basis of abnormal urinalysis and underwent renal biopsy procedures. Among the 29 children, 14 cases of IgA nephropathy were confirmed. During the same period, of the children examined by means other than the school screening program, 20 demonstrated suspected renal disease and underwent renal biopsies. Among these 20 children, 6 cases of IgA nephropathy were diagnosed. In all, 20 cases of pediatric IgA nephropathy were detected over the past 17 years. The incidence rate of pediatric IgA nephropathy was 4.5 cases/year per 100,000 children under 15 years. The incidence of pediatric IgA nephropathy is higher than that of idiopathic nephrotic syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yoshikawa N, Tanaka R, Iijima K (2001) Pathophysiology and treatment of IgA nephropathy in children. Pediatr Nephrol 16:446–457

    Article  CAS  PubMed  Google Scholar 

  2. Kitajima T, Murakami M, Sakai O (1983) Clinicopathological features in Japanese patients with IgA nephropathy. Jpn J Med 22:219–222

    CAS  PubMed  Google Scholar 

  3. Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan Y-L, Jackson B (1977) IgA nephropathy: a syndrome of uniform morphology, diverse clinical features, and uncertain prognosis. Clin Nephrol 8:459–471

    CAS  PubMed  Google Scholar 

  4. Hood SA, Velosa JA, Holley KE, Donadio JV Jr (1981) IgA-IgG nephropathy: predictive indices of progressive disease. Clin Nephrol 16:55–62

    CAS  PubMed  Google Scholar 

  5. Sissons JGP, Woodrow DF, Curtis JR, Evans DJ, Gover PE, Sloper JC, Peters DK (1975) Isolated glomerulonephritis with mesangial IgA deposits. BMJ 3:611–614

    CAS  PubMed  Google Scholar 

  6. Yoshikawa N, Matsuo T (1984) IgA nephropathy in children. Compr Ther 10:35–41

    CAS  Google Scholar 

  7. Yoshikawa N, Iijima K, Ito H (1999) IgA nephropathy in children. Nephron 83:1–12

    Article  CAS  PubMed  Google Scholar 

  8. Schlesinger ER, Schultz HA (1968) The nephrotic syndrome. Its incidence and implications for the community. Am J Dis Child 116:623–632

    CAS  PubMed  Google Scholar 

  9. McKinney PA, Feltbower RG, Brocklebank JT, Fitzpatrick MM (2001) Time trends and ethnic patterns of childhood nephrotic syndrome in Yorkshire, UK. Pediatr Nephrol 16:1040–1044

    Article  CAS  PubMed  Google Scholar 

  10. Wyatt RJ, Julian BA, Baehler RW, Stafford CC, McMorrow RG, Ferguson T, Jackson E, Woodford SY, Miller PM, Kritchevsky S (1998) Epidemiology of IgA nephropathy in central and eastern Kentucky for the period 1975 through 1994. J Am Soc Nephrol 9:553–558

    Google Scholar 

  11. Sehic AM, Gaber LW, Roy S 3rd, Miller PM, Kritchevsky SB, Wyatt RJ (1997) Increased recognition of IgA nephropathy in African-American Children. Pediatr Nephrol 11:435–437

    Article  CAS  PubMed  Google Scholar 

  12. D'Amico G (1987) The commonest glomerulonephritis in the world: IgA nephropathy. QJM 64:709–727

    CAS  PubMed  Google Scholar 

  13. Droz D, Kramar A, Nawer T, Noel LH (1984) Primary IgA nephropathy: prognostic factors. Contrib Nephrol 40:202–207

    CAS  PubMed  Google Scholar 

  14. Wyatt RJ, Kritchevsky SB, Woodford SY, Miller PM, Roy S 3rd, Holland NH, Jackson E, Bishof NA (1995) IgA nephropathy: long-term prognosis for pediatric patients. J Pediatr 127:913–919

    CAS  PubMed  Google Scholar 

  15. Wyatt RJ, Hogg RJ (2001) Evidence-based assessment of treatment options for children with IgA nephropathies. Pediatr Nephrol 16:156–167

    Article  CAS  PubMed  Google Scholar 

  16. Yoshikawa N, Ito H, Sasaki T, Takekoshi Y, Masataka M, Nakagawa K, Nakamura H, Matsuyama M, Seino Y, Takeda Y, Hattori S, Ninomiya M (1999) A controlled trial of combined therapy for newly diagnosed severe childhood IgA nephropathy. J Am Soc Nephrol 10:101–109

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Tottori University, 36–1 Nishi-machi, Yonago 683–8504, Japan

    Yasushi Utsunomiya, Takayuki Koda, Tadashi Kado, Sinichi Okada, Atsushi Hayashi & Susumu Kanzaki

  2. Department of Nursing, Institute of Medical Care Technology, Tottori University, Yonago 683–8504, Japan

    Tsunakiyo Kasagi

  3. Department of Pediatrics, Yonago National Hospital, Yonago 683–0006, Japan

    Hiroshi Hayashibara

  4. Okasora Pediatric Office, Sakaiminato 684–0003, Japan

    Teruo Okasora

Authors
  1. Yasushi Utsunomiya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takayuki Koda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tadashi Kado
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sinichi Okada
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Atsushi Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Susumu Kanzaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Tsunakiyo Kasagi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hiroshi Hayashibara
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Teruo Okasora
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yasushi Utsunomiya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Utsunomiya, Y., Koda, T., Kado, T. et al. Incidence of pediatric IgA nephropathy. Pediatr Nephrol 18, 511–515 (2003). https://doi.org/10.1007/s00467-003-1127-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00467-003-1127-z

Keywords

Search

Navigation