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Does growth hormone treatment affect the risk of post-transplant renal cancer?

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Abstract.

According to the analysis of the Collaborative Transplant Study (CTS), the incidence of renal carcinoma in patients with renal transplantation as well as with heart transplantation is significantly increased at any given patient age. The cumulative incidence 10 years after kidney transplantation is 185 per 100,000 patients in children below the age of 19 years at the time of transplantation. Age and immunosuppressive treatment seem to be the major risk factors. The majority of cancers develop within the native kidneys. Chronic transplant nephropathy and accelerated senescence may be further risk factors for the development of cancer within a kidney transplant. Growth hormone (GH) treatment could not be identified as an additional risk factor.

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Authors and Affiliations

  1. Division of Pediatric Nephrology, University Children's Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany, , , , ,

    Otto Mehls

  2. KIGS/KIMS Outcome Research, Pharmacia AB, Stockholm, Sweden, , , , ,

    Pattrick Wilton

  3. Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands, , , , ,

    Mark Lilien

  4. Karolinska Institutet, Department of Pediatrics, Huddinge University Hospital, Stockholm, Sweden, , , , ,

    Ulla Berg

  5. Service de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Paris, France, , , , ,

    Michel Broyer

  6. Divisione di Nefrologia e Dialisi, Ospedale Pediatrico Bambino Gesú, Rome, Italy, , , , ,

    Gianfranco Rizzoni

  7. Institute of Pathology, Heidelberg, Germany, , , , ,

    Rüdiger Waldherr

  8. Department of Immunology, University of Heidelberg, Heidelberg, Germany, , , , ,

    Gerhard Opelz

Authors
  1. Otto Mehls
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  2. Pattrick Wilton
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  3. Mark Lilien
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  4. Ulla Berg
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  5. Michel Broyer
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  6. Gianfranco Rizzoni
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  7. Rüdiger Waldherr
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  8. Gerhard Opelz
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Mehls, O., Wilton, P., Lilien, M. et al. Does growth hormone treatment affect the risk of post-transplant renal cancer?. Pediatr Nephrol 17, 984–989 (2002). https://doi.org/10.1007/s00467-002-0962-7

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  • DOI: https://doi.org/10.1007/s00467-002-0962-7

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