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Long-term weight loss outcomes after bariatric surgery: a propensity score study among patients with psychiatric disorders

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Abstract

Introduction

To analyze the safety and long-term result of bariatric surgery in patients with psychiatric disorders.

Material and methods

From January 2009 to December 2018, n = 961 patients underwent bariatric surgery in a tertiary center. Among them, two groups of patients were created: a group of patients with psychiatric disorders (PG) and a group without psychiatric disorders (CG), using a propensity score matched (PSM). Primary endpoint was long-term outcomes and secondary endpoints were the postoperative morbidity 90 days after surgery, late morbidity, occurrence of psychiatric adverse events, and resolution of obesity-related comorbidities.

Results

Analysis with PSM permitted to compare 136 patients in each group, with a ratio 1:1. TWL% at 2 years in the PG was 32.7% versus 36.6% in the CG (p = 0.002). Overall surgical morbidity was higher in the PG than the CG (28% vs 17%, p = 0.01). Severe surgical complications were not statistically significant (4% vs 3%, p = 0.44). Psychiatric adverse events were significantly more frequent in the PG than in the CG. The resolution of obesity comorbidities was equivalent for both groups at 2 years.

Conclusion

Substantial weigh loss was reported among patients with psychiatric disorders receiving bariatric surgery at the cost of more non-severe surgical complications. Further, a psychiatric postoperative follow-up visit may be warranted for patients with preoperative psychiatric disorders, given the incidence of psychiatric adverse events.

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Authors and Affiliations

  1. Department of Digestive Surgery, University Hospital of Caen, Avenue de la côte de Nacre, 14033, Caen Cedex, France

    Ludovic Dupont, Arnaud Alves, Adrien Lee Bion, Hugo Meunier & Benjamin Menahem

  2. UFR de Médecine, 2 avenue des Rochambelles, CS 60001, 14033, Caen Cedex, France

    Arnaud Alves, Eric Bui, Jean-Jacques Parienti & Benjamin Menahem

  3. UMR INSERM 1086 “Cancers et preventions”, Centre François Baclesse, 3 avenue du Général Harris, 14045, Caen Cedex, France

    Arnaud Alves & Benjamin Menahem

  4. Department of Psychiatry, University Hospital of Caen, Avenue de la côte de Nacre, 14033, Caen Cedex, France

    Eric Bui

  5. UNICAEN, INSERM, U1237, PhIND «Physiopathology and Imaging of Neurological Disorders», NEUROPRESAGE Team, Institut Blood and Brain @ Caen-Normandie, Caen University Hospital and Normandie University, Cyceron, 14000, Caen, France

    Eric Bui

  6. Department of Biostatistics, University Hospital of Caen, Avenue de la côte de Nacre, 14033, Caen Cedex, France

    Anaïs Briant & Jean-Jacques Parienti

  7. Department of Digestive Surgery, University Hospital of Caen, Avenue de la cote de Nacre, 14032, Caen Cedex, France

    Benjamin Menahem

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  1. Ludovic Dupont
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Correspondence to Benjamin Menahem.

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Ludovic Dupont, Benjamin Menahem, Jean-Jacques Parienti, Arnaud Alves, Eric Bui, Adrien Lee Bion, Hugo Meunier, and Anaïs Briant have no conflicts of interest or financial ties to disclose.

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Dupont, L., Alves, A., Bui, E. et al. Long-term weight loss outcomes after bariatric surgery: a propensity score study among patients with psychiatric disorders. Surg Endosc 37, 8362–8372 (2023). https://doi.org/10.1007/s00464-023-10343-z

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