Abstract
Background
Conventional open and conventional laparoscopic splenectomy and azygoportal disconnection (CLSD) result in poor quality of life because of damage to the vagal nerve. We have developed vagus nerve-preserving laparoscopic splenectomy and azygoportal disconnection (VLSD). This study aimed to evaluate whether VLSD is effective and safe, and to determine whether a reduction in the incidence of postoperative complications improves postoperative quality of life compared with CLSD.
Methods
We retrospectively evaluated outcomes in 72 cirrhotic patients with portal hypertensive bleeding and secondary hypersplenism who underwent CLSD (n = 40) or VLSD (n = 32) between April 2015 and December 2016. Their demographic, intraoperative, and postoperative variables were compared.
Results
No patients required conversion to laparotomy in CLSD and VLSD. There was no difference in estimated intraoperative blood loss, volume of intraoperative blood transfused, time to first flatus, time to off-bed activity, and postoperative hospital stay between the two groups. VLSD was associated with a shorter operation time (P = 0.020) and less postoperative complications (P < 0.0001), including less diarrhea (P < 0.0001), epigastric fullness (P < 0.0001), and delayed gastric emptying (P < 0.0001), compared with CLSD. With VLSD, there was a significant increase in body weight and plasma albumin levels at 6 months postoperatively compared with preoperative values (all P < 0.05). The curative effect of improving esophageal/gastric variceal bleeding was similar in the groups.
Conclusions
VLSD is effective and safe for reducing the incidence of postoperative complications, contributing to improving postoperative quality of life.
Similar content being viewed by others
References
Yu H, Guo S, Wang L, Dong Y, Tian G, Mu S, Zhang H, Li D, Zhao S (2016) Laparoscopic splenectomy and esophagogastric devascularization for liver cirrhosis and portal hypertension is a safe, effective, and minimally invasive operation. Laparoendosc Adv Surg Tech A 26:524–530
Bai DS, Qian JJ, Chen P, Yao J, Wang XD, Jin SJ, Jiang GQ (2014) Modified laparoscopic and open splenectomy and azygoportal disconnection for portal hypertension. Surg Endosc 28:257–264
Zhe C, Jian-wei L, Jian C, Yu-dong F, Ping B, Shu-guang W, Shu-guo Z (2013) Laparoscopic versus open splenectomy and esophagogastric devascularization for bleeding varices or severe hypersplenism: a comparative study. J Gastrointest Surg 17:654–659
Zheng X, Liu Q, Yao Y (2013) Laparoscopic splenectomy and esophagogastric devascularization is a safe, effective, minimally invasive alternative for the treatment of portal hypertension with refractory variceal bleeding. Surg Innov 20:32–39
Kim HH, Park MI, Lee SH, Hwang HY, Kim SE, Park SJ, Moon W (2012) Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy. World J Gastroenterol 18:4044–4050
Murakami H, Matsumoto H, Kubota H, Higashida M, Nakamura M, Hirai T (2013) Evaluation of electrical activity after vagus nerve-preserving distal gastrectomy using multichannel electrogastrography. J Smooth Muscle Res 49:1–14
Jiang G, Qian J, Yao J, Wang X, Jin S, Bai D (2014) A new technique for laparoscopic splenectomy and azygoportal disconnection. Surg Innov 21:256–262
Jiang GQ, Bai DS, Chen P, Qian JJ, Jin SJ, Yao J, Wang XD (2014) Modified laparoscopic splenectomy and azygoportal disconnection combined with cell salvage is feasible and might reduce the need for blood transfusion. World J Gastroenterol 20:18420–18426
Tomita R, Fujisaki S, Tanjoh K, Fukuzawa M (2000) Relationship between gastroduodenal interdigestive migrating motor complex and quality of life in patients with distal subtotal gastrectomy for early gastric cancer. Int Surg 85:118–123
Tomita R, Tanjoh K, Fujisaki S (2004) Novel operative technique for vagal nerveand pyloric sphincter-preserving distal gastrectomy reconstructed by interposition of a 5 cm jejunal J pouch with a 3 cm jejunal conduit for early gastric cancer and postoperative quality of life 5 years after operation. World J Surg 28:766–774
Adams JF (1967) The clinical and metabolic consequences of total gastrectomy. I. Morbidity, weight, and nutrition. Scand J Gastroenterol 2:137–149
Tomita R, Fujisaki S, Tanjoh K, Fukuzawa M (2001) Operative technique on nearly total gastrectomy reconstructed by interposition of a jejunal J pouch with preservation of vagal nerve, lower esophageal sphincter, and pyloric sphincter for early gastric cancer. World J Surg 25:1524–1531
Tomita R, Fujisaki S, Tanjoh K, Fukuzawa M (2003) Studies on gastrointestinal hormone and jejunal nterdigestive migrating motor complex in patients with or without early dumping syndrome after total gastrectomy with Roux-en-Y reconstruction for early gastric cancer. Am J Surg 185:354–359
Kojima K, Yamada H, Inokuchi M, Kawano T, Sugihara K (2008) Functional evaluation after vagusnerve-sparing laparoscopically assisted distal gastrectomy. Surg Endosc 22:2003–2008
Kim SM, Cho J, Kang D, Oh SJ, Kim AR, Sohn TS, Noh JH, Kim S (2016) A randomized controlled trial of vagus nerve-preserving distal gastrectomy versus conventional distal gastrectomy for postoperative quality of life in early stage gastric cancer patients. Ann Surg 263:1079–1084
Datta J, Williams NN, Conway RG, Dempsey DT, Morris JB (2014) Rescue pyloroplasty for refractory delayed gastric emptying following esophagectomy. Surgery 156:290–297
Shimoda M, Kubota K, Katoh M, Kita J (2013) Effect of billroth II or Roux-en-Y reconstruction for the gastrojejunostomy on delayed gastric emptying after pancreaticoduodenectomy: a randomized controlled study. Ann Surg 257:938–942
Hanna MM, Gadde R, Allen CJ, Meizoso JP, Sleeman D, Livingstone AS, Merchant N, Yakoub D (2016) Delayed gastric emptying after pancreaticoduodenectomy. J Surg Res 202:380–388
Jiang XZ, Zhao SY, Luo H, Huang B, Wang CS, Chen L, Tao YJ (2009) Laparoscopic and open splenectomy and azygoportal disconnection for portal hypertension. World J Gastroenterol 15:3421–3425
Xin Z, Qingguang L, Yingmin Y (2009) Total laparoscopic versus open splenectomy and esophagogastric devascularization in the management of portal hypertension: a comparative study. Dig Surg 26:499–505
Jiang GQ, Chen P, Qian JJ, Yao J, Wang XD, Jin SJ, Bai DS (2014) Perioperative advantages of modified laparoscopic vs open splenectomy and azygoportal disconnection. World J Gastroenterol 20:9146–9157
Isozaki H, Okajima K, Momura E, Ichinona T, Fujii K, Izumi N, Takeda Y (1996) Postoperative evaluation of pylorus-preserving gastrectomy for early gastric cancer. Br J Surg 83:266–269
Ihasz M, Griffith CA (1981) Gallstones after vagotomy. Am J Surg 141:48–50
Hibbard ML, Dunst CM, Swanström LL (2011) Laparoscopic and endoscopic pyloroplasty for gastroparesis results in sustained symptom improvement. J Gastrointest Surg 15:1513–1519
Binswanger RO, Aeberhard P, Walther M, Vock P (1978) Effect of pyloroplasty on gastric emptying: long term results as obtained with a labelled test meal 14–43 months after operation. Br J Surg 65:27–29
Acknowledgements
This work was supported by the Scientific Research Subject of Jiangsu Province Health Department (No. H201661) and the Project of Invigorating Health Care through Science, Technology and Education: Jiangsu Provincial Medical Youth Talent (QNRC2016331).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Disclosure
Drs. Dou-Sheng Bai, Ping Chen, Sheng-Jie Jin, Jian-Jun Qian, and Guo-Qing Jiang have no conflicts of interest or financial ties to disclose.
Rights and permissions
About this article
Cite this article
Bai, DS., Chen, P., Jin, SJ. et al. Vagus nerve-preserving versus conventional laparoscopic splenectomy and azygoportal disconnection. Surg Endosc 32, 2696–2703 (2018). https://doi.org/10.1007/s00464-017-5965-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00464-017-5965-3