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C-reactive protein can be an early predictor of postoperative complications after gastrectomy for gastric cancer

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An Erratum to this article was published on 01 November 2016

Abstract

Background

The clinical outcomes for postoperative complications (PCs) after gastrectomy depend on early diagnosis and intensive treatment. The aim of this study was to investigate the role of C-reactive protein (CRP) as an early predictor of PCs after gastrectomy for gastric cancer.

Methods

A total of 334 consecutive patients who underwent gastrectomy for gastric cancer in 2014 were enrolled in this study. Blood samples were obtained preoperatively, and at postoperative days 1 and 4 for the measurement of inflammatory markers (white blood cell, neutrophil, and platelet counts, and CRP). Patients were classified into groups of major and minor/no PCs, which were defined as patients with PCs of more than grade III and those with grade I/II or without PCs, respectively, according to the Clavien–Dindo classification.

Results

Twenty-five patients developed major PCs. The CRP on postoperative day 4 provided superior diagnostic accuracy in predicting major PCs compared to the other systematic inflammatory markers. Multivariate analysis identified a CRP level of 16.8 mg/dl or greater on postoperative day 4 as a significant predictive factor for major PCs.

Conclusions

Among the various systemic inflammatory markers, CRP on postoperative day 4 is the most reliable predictor of PCs after gastrectomy for gastric cancer.

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Acknowledgments

The statistical consultation was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HI14C1062).

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Authors and Affiliations

  1. Division of Gastrointestinal Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, Korea

    Eun Young Kim, Cho Hyun Park & Kyo Young Song

  2. Clinical Research Coordinating Center of Catholic Medical Center, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Hyun Woo Yim

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  1. Eun Young Kim
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  2. Hyun Woo Yim
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Correspondence to Kyo Young Song.

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Disclosures

Drs. Eun Young Kim, Hyun Woo Yim, Cho Hyun Park, and Kyo Young Song have no conflicts of interest or financial ties to disclose.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s00464-016-5307-x.

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Kim, E.Y., Yim, H.W., Park, C.H. et al. C-reactive protein can be an early predictor of postoperative complications after gastrectomy for gastric cancer. Surg Endosc 31, 445–454 (2017). https://doi.org/10.1007/s00464-016-5272-4

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  • DOI: https://doi.org/10.1007/s00464-016-5272-4

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