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Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection

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Abstract

Objective

To determine whether the joint implementation of immunonutrition and a laparoscopic approach improves morbidity, mortality, and length of stay (LOS) compared with dietary advice.

Background

Despite progress in recent years in the surgical management of patients with colorectal cancer, postoperative complications are frequent. Nutritional supplements enriched with immunonutrients have recently been introduced into clinical practice. However, the immunonutrition benefits in patients undergoing colorectal laparoscopic surgery are unknown.

Methods

This study was a prospective, randomized trial with two parallel treatment groups receiving an immune-enhancing dietary supplement for 7 days before colorectal resection and 5 days postoperatively or dietary advice.

Results

A total of 128 patients were randomized. At baseline, both groups were comparable with respect to age, sex, surgical risk, comorbidities, and analytical and nutritional parameters. The median postoperative LOS was 5 days and was not significantly different between the groups. Wound infection differed significantly between the groups (11.50 vs. 0.00 %, p = 0.006). No other differences between the groups were identified.

Conclusions

The joint use of laparoscopy and supplementation with immunonutrients reduces surgical wound infection in patients undergoing colorectal surgery.

Trial registration

This study is registered with ClinicalTrial.gov: NCT0239396.

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Acknowledgments

This study was supported by a scholarship from La Fundación de la Mutua Madrileña.

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Authors and Affiliations

  1. Department of Surgery and Pathology, University Miguel Hernandez of Elche, Elche, Spain

    Pedro Moya, Leticia Soriano-Irigaray, Antonio Arroyo, Fernando Candela & Rafael Calpena

  2. Division of Colorectal Surgery, Department of General Surgery, University General Hospital of Elche, Elche, Spain

    Pedro Moya, Antonio Arroyo, Maria-del-Mar Aguilar, Marta Bellón, Fernando Candela & Rafael Calpena

  3. Department of Anaesthesia, University General Hospital of Elche, Elche, Spain

    Elena Miranda & Jose-Luis Muñoz

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  1. Pedro Moya
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Correspondence to Pedro Moya.

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Disclosures

Pedro Moya, Elena Miranda, Leticia Soriano-Irigaray, Antonio Arroyo, Maria-del-Mar Aguilar, Marta Bellón, Jose-Luis Muñoz, Fernando Candela, and Rafael Calpena have no conflicts of interest or financial ties to disclose.

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Moya, P., Miranda, E., Soriano-Irigaray, L. et al. Perioperative immunonutrition in normo-nourished patients undergoing laparoscopic colorectal resection. Surg Endosc 30, 4946–4953 (2016). https://doi.org/10.1007/s00464-016-4836-7

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  • DOI: https://doi.org/10.1007/s00464-016-4836-7

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