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Risk factors for prolonged ileus following colon surgery

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Abstract

Background

Prolonged ileus is one of the most common postoperative complications after colorectal surgery. We sought to investigate the predictors of prolonged ileus following elective colon resections procedures.

Methods

The national participant user files of NSQIP databases were utilized to examine the clinical outcomes of patients undergoing elective colon resection during 2012–2013. Multivariate regression analysis was performed to investigate predictors of prolonged ileus. Prolonged ileus was defined as no return of bowel function in 7 days.

Results

We sampled a total of 27,560 patients who underwent colon resections; of these, 3497 (12.7 %) patients had prolonged ileus. Patients with ileocolonic anastomosis (ICA) had a significantly higher rate of prolonged ileus compared to patients with colorectal anastomosis (CRA) (15 vs. 11.5 %, AOR 1.25, P < 0.01). Prolonged ileus was significantly associated with intra-abdominal infections (13 vs. 2.8 %, AOR 2.56, P < 0.01) and anastomotic leakage (12 vs. 2.4 %, AOR 2.50, P < 0.01). Factors such as preoperative sepsis (AOR 1.63, P < 0.01), disseminated cancer (AOR 1.24, P = 0.01), and chronic obstructive pulmonary disease (AOR 1.27, P = 0.02) were associated with an increased risk of prolonged ileus, whereas oral antibiotic bowel preparation (AOR 0.77, P < 0.01) and laparoscopic surgery (AOR 0.51, P < 0.01) are associated with decreased prolonged ileus risk.

Conclusions

Prolonged ileus is a common condition following colon resection, with an incidence of 12.7 %. Among colon surgeries, colectomy with ICA resulted in the highest rate of postoperative prolonged ileus. Prolonged ileus is positively associated with anastomotic leak and intra-abdominal infections; thus, a high index of suspicion must be had in all patients with prolonged postoperative ileus.

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Disclosures

Dr. Stamos has received educational grants and speaker fees paid to the Department of Surgery, University of California, Irvine, from Ethicon, Gore, Covidien, and Olympus. Dr. Mills and Dr. Carmichael received Ethicon educational grants paid to the Department of Surgery, University of California, Irvine. Dr. Pigazzi is a consultant for Intuitive Surgical and has also received consultancy fees and educational grants paid to the Department of Surgery, University of California, Irvine. Dr. Moghadamyeghaneh, Dr. Phelan, Dr. Hwang, and Dr. Hanna have no disclosures. Dr. Moghadamyeghaneh had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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Authors and Affiliations

  1. Department of Surgery, University of California, Irvine, School of Medicine, Irvine, CA, USA

    Zhobin Moghadamyeghaneh, Grace S. Hwang, Mark H. Hanna, Joseph C. Carmichael, Steven Mills, Alessio Pigazzi & Michael J. Stamos

  2. Department of Statistics, University of California, Irvine, CA, USA

    Michael Phelan

  3. John E. Connolly Chair in Surgery, 333 City Blvd. West Suite 1600, Orange, CA, 92868, USA

    Michael J. Stamos

Authors
  1. Zhobin Moghadamyeghaneh
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  2. Grace S. Hwang
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  3. Mark H. Hanna
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  4. Michael Phelan
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  5. Joseph C. Carmichael
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  6. Steven Mills
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  7. Alessio Pigazzi
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  8. Michael J. Stamos
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Correspondence to Michael J. Stamos.

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Moghadamyeghaneh, Z., Hwang, G.S., Hanna, M.H. et al. Risk factors for prolonged ileus following colon surgery. Surg Endosc 30, 603–609 (2016). https://doi.org/10.1007/s00464-015-4247-1

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  • DOI: https://doi.org/10.1007/s00464-015-4247-1

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