Skip to main content

Advertisement

Log in

Gastrointestinal stromal tumors of the stomach: the role of laparoscopic resection. Single-centre experience of 38 cases

  • Technique
  • Published:
Surgical Endoscopy Aims and scope Submit manuscript

Abstract

Introduction

Laparoscopic resection is considered the gold standard of treatment only for small gastric gastrointestinal stromal tumor (GIST).

Materials and Methods

Between January 2004 and September 2012, 38 consecutive gastric GISTs were operated on by laparoscopic approach, without conversions. Thirty-five cases were primary GISTs and three were bleeding GISTs with hepatic metastases non-responding to conservative therapy treated by emergency surgery.

Results

Median tumor size was 3.63 cm (1.8–17 cm). In two cases tumor size was <2 cm, between 2 and 5 cm in 26 cases, between 5 and 10 cm in eight cases, and >10 cm in two cases. In two cases, localization was in the cardia, fundus in ten cases, lesser curve in 11 cases, greater curve in 12 cases, and antrum in three cases. We performed 24 wedge resections, eight transgastric resections and six antrectomies. An Endo-GIA™ was used in 25 cases, and a manual laparoscopic reconstruction with extramucosal suture was performed in 13 cases. No postoperative mortality and morbidity was observed. The routine use of laparoscopy allowed us to perform resections in 100 % of cases, even in those where preoperative imaging suggested an open approach according to the current guidelines.

Conclusions

The use of a pre-resection endobag avoids spillage and seeding, thus increasing the possibility of resection. In conclusion, we consider the laparoscopic approach as mandatory in all cases, always considering the possibility of converting to the open technique when necessary.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Sexton JA, Pierce RA, Halpin VJ, Eagon JC, Hawkins WG, Linehan DC, Brunt LM, Frisella MM, Matthews BD (2008) Laparoscopic gastric resection for gastrointestinal stromal tumors. Surg Endosc 22:2583–2587

    Article  PubMed  Google Scholar 

  2. Kindblom LG, Remotti HE, Aldenborg F, Meis-Kindblom JM (1998) Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol 152:1259–1269

    CAS  PubMed  Google Scholar 

  3. Kitamura Y, Hirota S, Nishida T (1998) Molecular pathology of c-kit proto-oncogene and development of gastrointestinal stromal tumors. Ann Chir Gynaecol 87(4):282–286

    CAS  PubMed  Google Scholar 

  4. Debiec-Rychter M, Wasag B, Stul M, De Wever I, Van Oosterom A, Hagemeijer A, Sciot R (2004) Gastrointestinal stromal tumours (GISTs) negative for KIT (CD117 antigen) immunoreactivity. J Pathol 202(4):430–438

    Article  CAS  PubMed  Google Scholar 

  5. Blay J-Y, Bonvalot S, Casali P, Choi H, Debiec-Richter M, Dei Tos AP, Emile J-F, Gronchi A, Hogendoorn PCW, Joensuu H, Le Cesne A, Mac Clure J, Maurel J, Nupponen N, Ray-Coquard I, Reichardt P, Sciot R, Stroobants S, van Glabbeke M, van Oosterom A, Demetri GD (2005) Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20–21 March 2004, under the auspices of ESMO. Ann Oncol 16:566–578

    Article  PubMed  Google Scholar 

  6. Liegl B, Hornick JL, Corless CL, Fletcher CD (2009) Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes. Am J Surg Pathol 33(3):437–446

    Article  PubMed  Google Scholar 

  7. Miettinen M, Wang ZF, Lasota J (2009) DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1,840 cases. Am J Surg Pathol 33(9):1401–1408

    Article  PubMed  Google Scholar 

  8. Dematteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, Blackstein ME, Blanke CD, von Mehren M, Brennan MF, Patel S, McCarter MD, Polikoff JA, Tan BR, Owzar K, American College of Surgeons Oncology Group (ACOSOG), Intergroup Adjuvant GIST Study Team (2009) Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumor: a randomized double-blind placebo-controlled trial. Lancet 373:1097–10104

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Gleevec/Glivec prescribing information. Available from: http://www.pharma.us.novartis.com/product/pi/pdf/gleevec_tabs.pdf. Accessed 8 May 2013

  10. Choi H, Charnsangavej C, Faria SC, Macapinlac HA, Burgess MA, Patel SR, Chen LL, Podoloff DA, Benjamin RS (2007) Correlation of computed tomography and positron emission tomography in patients with metastatic gastrointestinal stromal tumor treated at a single institution with imatinib mesylate: proposal of new computed tomography response criteria. J Clin Oncol 25(13):1753–1759

    Article  PubMed  Google Scholar 

  11. Otani Y, Furukawa T, Yoshida M, Saikawa Y, Wada N, Ueda M, Kubota T, Mukai M, Kameyama K, Sugino Y, Kumai K, Kitajima M (2006) Operative indications for relatively small (2–5 cm) gastrointestinal stromal tumor of the stomach based on analysis of 60 operated cases. Surgery 139(4):484–492

    Article  PubMed  Google Scholar 

  12. Privette A, McCahill L, Borrazzo E, Single RM, Zubarik R (2008) Laparoscopic approaches to resection of suspected gastric gastrointestinal stromal tumors based on tumor location. Surg Endosc 22:487–494

    Article  CAS  PubMed  Google Scholar 

  13. Rivera RE, Eagon JC, Soper NJ, Klingensmith ME, Brunt LM (2005) Experience with laparoscopic gastric resection. Surg Endosc 19:1622–1626

    Article  CAS  PubMed  Google Scholar 

  14. Wilhelm D, von Delius S, Burian M, Schneider A, Frimberger E, Meining A, Feussner H (2008) Simultaneous use of laparoscopy and endoscopy for minimally invasive resection of gastric subepithelial masses: analysis of 93 interventions. World J Surg 32:1021–1028

    Article  CAS  PubMed  Google Scholar 

  15. Fletcher CD (2002) Clinicopathologic correlations in gastrointestinal stromal tumors. Hum Pathol 33(5):455

    Article  PubMed  Google Scholar 

  16. Carboni F, Carlini M, Scardamaglia F, Santoro EM, Boschetto A, Castelli M, Marandino F, Santoro E (2003) Gastrointestinal stromal tumor of the stomach: a ten-year surgical experience. J Exp Clin Cancer Res 22(3):379–383

    CAS  PubMed  Google Scholar 

  17. McCarter MD, Antonescu CR, Ballman KV, Maki RG, Pisters PW, Demetri GD, Blanke CD, von Mehren M, Brennan MF, McCall L, Ota DM, DeMatteo RP, American College of Surgeons Oncology Group (ACOSOG), Intergroup Adjuvant Gist Study Team (2012) Microscopically positive margins for primary gastrointestinal stromal tumors: analysis of risk factors and tumor recurrence. J Am Coll Surg 215(1):53–59 Discussion 59–60

    Article  PubMed Central  PubMed  Google Scholar 

  18. Koh YX, Chok AY, Zheng HL, Tan CS, Chow PK, Wong WK, Goh BK (2013) A systematic review and metanalysis comparing laparoscopic versus open gastrectomy for gastrointestinal stromal tumors of the stomach. Ann Surg Oncol 20:3549–3560

    Article  PubMed  Google Scholar 

  19. De Vogelaere K, Hoorens A, Haentjens P, Delvaux G (2013) Laparoscopic versus opens resection of gastrointestinal stromal tumors of the stomach. Surg Endosc 27(5):1546–1554

    Article  PubMed  Google Scholar 

  20. Melstrom LG, Phillips JD, Bentrem DJ, Wayne JD (2012) Laparoscopic versus open resection of gastric gastrointestinal stromal tumors. Am J Clin Oncol 35(5):451–454

    Article  PubMed  Google Scholar 

  21. Kim KH, Kim MC, Jung GJ, Kim SJ, Jang JS, Kwon HC (2012) Long term survival for gastric GIST: is laparoscopic surgery for large gastric GIST feasible ? World J Surg Oncol 31(10):230–238

    Article  Google Scholar 

  22. De Vogelaere K, Van Loo I, Peters O, Hoorens A, Haentjens P, Delvaux G (2012) Laparoscopic resection of gstric gastrointestinal stromal tumors (GIST) is safe and effective, irrespective of tumor size. Surg Endosc 26(8):2339–2345

    Article  PubMed  Google Scholar 

  23. Mullady DK, Tan BR (2013) A multidisciplinary approach to the diagnosis and treatment of gastrointestinal stromal tumors. J Clin Gastroenterol 47(7):578–585

    Article  CAS  PubMed  Google Scholar 

Download references

Disclosures

Mario Valle, Orietta Federici, Fabio Carboni, Silvia Carpano, Michele Benedetti and Alfredo Garofalo have no conflicts of interest or financial ties to disclose.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mario Valle.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Valle, M., Federici, O., Carboni, F. et al. Gastrointestinal stromal tumors of the stomach: the role of laparoscopic resection. Single-centre experience of 38 cases. Surg Endosc 28, 1040–1047 (2014). https://doi.org/10.1007/s00464-013-3255-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00464-013-3255-2

Keywords

Navigation