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Factors related to the curability of early gastric cancer with endoscopic submucosal dissection

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Abstract

Background

Endoscopic submucosal dissection (ESD) yields substantially high rates for curative resection of early gastric cancer (EGC). It is suggested that larger, ulcerative, or upper EGCs may prevent successful ESD. A detailed analysis of factors associated with the curability of ESD was performed.

Methods

Endoscopic submucosal dissection was performed for patients with EGC that fulfilled the expanded criteria, which specified mucosal cancer without ulcer findings irrespective of tumor size, mucosal cancer with ulcers 3 cm in diameter or smaller, and minute submucosal invasive cancer 3 cm or smaller. Resectability (en bloc or by piecemeal resection), curability (curative or non-curative), and complications were assessed, and logistic regression analysis was used to analyze the related factors.

Results

Ulcerative EGCs showed a significantly higher risk associated with ESD on multivariate analysis. When the risk factors (tumor size, location, and ulcer findings) were combined, the larger EGCs (>30 mm) located in the upper third or ulcerative tumors located in the upper and middle portion of the stomach were at significantly higher risk of non-curative resection. Such lesions also were associated with increased risk of procedure-related perforation.

Conclusions

When risk factors including positive ulcer findings and larger size and upper location of tumors are combined, ESD should be performed more carefully.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Ken Ohnita, Hajime Isomoto, Naoyuki Yamaguchi, Eiichiro Fukuda, Takashi Nakamura, Hitoshi Nishiyama, Yohei Mizuta & Shigeru Kohno

  2. Department of Gastroenterology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Motohisa Akiyama & Kazuhiko Nakao

  3. Sankokai Miyazaki Hospital, 1575-1 Kuyama, Isahaya, 854-0066, Japan

    Saburo Shikuwa

Authors
  1. Ken Ohnita
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  2. Hajime Isomoto
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  3. Naoyuki Yamaguchi
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  4. Eiichiro Fukuda
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  5. Takashi Nakamura
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  6. Hitoshi Nishiyama
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  7. Yohei Mizuta
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  8. Motohisa Akiyama
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  9. Kazuhiko Nakao
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  10. Shigeru Kohno
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  11. Saburo Shikuwa
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Corresponding author

Correspondence to Hajime Isomoto.

Additional information

Ken Ohnita, Hajime Isomoto, and Naoyuki Yamaguchi equally contributed to this work.

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Ohnita, K., Isomoto, H., Yamaguchi, N. et al. Factors related to the curability of early gastric cancer with endoscopic submucosal dissection. Surg Endosc 23, 2713–2719 (2009). https://doi.org/10.1007/s00464-009-0473-8

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  • DOI: https://doi.org/10.1007/s00464-009-0473-8

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