Abstract
Background
Laparoscopic colectomy for malignant disease technically is feasible but not widely accepted because there are no large-series studies or data on long-term outcomes. A retrospective, multicenter study investigating a large series of patients was conducted in Japan to evaluate preliminary long-term results of laparoscopic surgery for colorectal cancer.
Methods
The study group comprised 2,036 patients who underwent laparoscopic colorectal resection April 1993 to August 2002 in 12 participating surgical units (Japanese Laparoscopic Surgery Study Group).
Results
Of the 1,495 patients with colon cancer, 781 (59%) had International Union Against Cancer (UICC) stage I, 248 (19%) had stage II, and 284 (22%) had stage III disease. Cancer recurred for 61 (4.1%) of 1,367 curatively treated patients (median follow-up period, 32 months; range, 6–125 months). The 5-year survival rate was 96.7% for stage I, 94.8% for stage II, and 79.6% for stage III disease. Of the 541 patients with rectal cancer, 220 (56%) had stage I, 62 had (16%) stage II, and 108 (28%) had stage III disease. Cancer recurred for 30 (5.6%) of 476 curatively treated patients (median follow-up period, 25 months; range 6–102 months). The 5-year survival rate was 95.2% for stage I, 85.2% for stage II, and 80.8% for stage III disease.
Conclusions
The findings indicate that laparoscopic surgery for colorectal cancer yields an oncological outcome as good as that reported for conventional open surgery in the Japanese Registry for all disease stages.
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References
Adachi Y, Sato K, Kakisako K, Inomata M, Shiraishi N, Kitano S (2003) Quality of life after laparoscopic or open colonic resection for cancer. Hepatogastroenterology 50: 1348–1351
Alexander RJ, Jaques BC, Mitchell KG (1993) Laparoscopically assisted colectomy and wound recurrence (letter). Lancet 341: 249–250
Curet MJ, Putrakul K, Pitcher DE, Josloff RK, Zucker KA (2000) Laparoscopically assisted colon resection for colon carcinoma; perioperative results and long-term outcome. Surg Endosc 14: 1062–1066
Fleshman JW, Nelson H, Peters WR, Kim HC, Larach S, Boorse RR, Ambroze W, Leggett P, Bleday R, Stryker S, Christenson B, Wexner S, Senagore A, Rattner D, Sutton J, Fine AP (1996) Early results of laparoscopic surgery for colorectal cancer: a retrospective analysis of 372 patients treated by clinical outcomes of Surgery Therapy (COST) Study Group. Dis Colon Rectum 39: S53–S58
Goh YC, Eu KW, Seow-Choen F (1997) Early postoperative results of a prospective series of laparoscopic vs open anterior resections for rectosigmoid cancers. Dis Colon Rectum 40: 776–780
Hasegawa H, Kabeshima Y, Watanabe M, Yamamoto S, Kitajima M (2003) Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer. Surg Endosc l7: 636–640
Hazebroek EJ, Color Study Group (2002) COLOR: a randomized clinical trial comparing laparoscopic and open resection for colon cancer. Surg Endosc 16: 949–953
Hirabayashi Y, Yamaguchi K, Shiraishi N, Adachi Y, Kitamura H, Kitano S (2002) Development of port-site metastasis after pneumoperitoneum: a scanning electron microscopy study. Surg Endosc 16: 864–868
Hong D, Tabet J, Anvari M (2001) Laparoscopic vs open resection for colorectal adenocarcinoma. Dis Colon Rectum 44: 10–19
Khallili TM, Fleshner PR, Hiatt JR, Sokol TP, Manookian C, Tsushima G, Phillips EH (1998) Colorectal cancer: comparison of laparoscopic with open approaches. Dis Colon Rectum 41: 832–838
Khonishi F, Okada M, Nagai H, Ozawa A, Kashiwagi H, Kanazawa K (1996) Laparoscopic-assisted colectomy with lymph node dissection for invasive carcinoma of the colon. Surg Today 26: 882–889
Lacy AM, Garcia-Valdecasas JC, Delgado S, Castells A, Taura P, Pique JM, Visa J (2002) Laparoscopy-assisted colectomy versus open colectomy for treatment of nonmetastatic colon cancer: a randomised trial. Lancet 29: 2224–2229
Milsom JW, Böhm B, Harnmerhofer KA, Fazio V, Steiger E, Elson P (1998) A prospective, randomized trial comparing laparoscopic versus conventional techniques in colorectal cancer surgery: a preliminary report. J Am Coll Surg 187: 46–55
Monson JR, Hill AD, Darzi A (1995) Laparoscopic colonic surgery (review). Br J Surg 82: 150–157
Multi-Institutional Registry of Large Bowel Cancer in Japan, Vol. 23 (2002) Cases treated in 1994. Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan
Nishiguchi K, Okuda J, Toyoda M, Tanaka K, Tanigawa N (2001) Comparative evaluation of surgical stress of laparoscopic and open surgeries for colorectal carcinoma. Dis Colon Rectum 44: 223–230
O’Rourke N, Price PM, Kelly S, Sikora K (1993) Tumour inoculation during laparoscopy (letter).Lancet 342: 368
Shiromizu A, Suematsu T, Yamaguchi K, Shiraishi N, Adachi Y, Kitano S (2000) Effect of laparotomy and laparoscopy on the establishment of lung metastasis in a murine model. Surgery 128: 799–805
Weeks JC, Nelson H, Gelber S, Sargent D, Schroeder G, Clinical Outcomes of Surgical Therapy (COST) Study Group (2002) Short-term quality-of-life outcomes following laparoscopic-assisted colectomy vs open colectomy for colon cancer: a randomized trial. JAMA 16: 321–328
Yamamoto S, Watanabe M, Hasegawa H, Kitajima M (2001) Oncologic outcome of laparocopic versus open surgery for advanced colorectal cancer. Hepatogastroenterology 48: 1248–1251
Acknowledgement
This work was supported in part by a Grant-in-Aid for Cancer Research from the Japanese Ministry of Health, Labour, and Welfare (No. 13-17). The following centers and surgeons participated in the multicenter study initiated by the Japanese Laparoscopic Surgery Study Group (JLSSG): Seigo Kitano, Norio Shiraishi, Masafumi Inomata, Oita University Faculty of Medicine (Oita); Masaki Kitajima, Kasuhiro Yasuda, Hirotoshi Hasegawa, Keio University School of Medicine (Tokyo); Fumio Konishi, Yutaka Kawamura, Omiya Medical Center Jichi Medical School (Omiya); Masahiko Watanabe, Kitasato University (Sagamitara); Susumu Satomi, Tohoku University Faculty of Medicine (Sendai); Nobuyoshi Shimizu, Okayama University Faculty of Medicine (Okayama); Masaki Fukunaga, Urayasu Hospital Juntendo University School of Medicine (Tokyo); Yoshinobu Sumiyama, Yoshihisa Saida, Ohashi Hospital Toho University School of Medicine (Tokyo); Shinei Kudo, Junichi Tanaka, Northern Yokohama Hospital Showa University (Yokohama); Nobuhiko Tanigawa, Junji Okuda, Osaka Medical University (Osaka), Tatsuro Yamakawa, Nobuyoshi Miyajima, Mizonoguchi Hospital Teikyo University (Tokyo), Hideo Yamada, Sakura National Hospital (Chiba), and Masao Nakata, Shikoku Cancer Center (Matsuyama).
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Kitano, S., Kitajima, M., Konishi, F. et al. A multicenter study on laparoscopic surgery for colorectal cancer in Japan. Surg Endosc 20, 1348–1352 (2006). https://doi.org/10.1007/s00464-004-8247-9
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DOI: https://doi.org/10.1007/s00464-004-8247-9