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The “stamp method”: a new treatment for perforated peptic ulcer?

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Abstract

Background

The aim of this study was to develop a simple method for closure of a perforated peptic ulcer, making it more accessible for laparoscopic surgery.

Methods

An experimental pilot study was performed using five male Wistar rats. The perforation was closed by a bioabsorbable patch made of lactide–glycolid–caprolactone fixed with glue onto the outside of the stomach.

Results

Postoperatively, there were no signs of leakage or other complications. Histologically, there were no signs of inflammation on the inside of the stomach, and there was a 50% reduction of the perforation each successive postoperative week. No adverse reactions because of the degradable material or glue were observed.

Conclusions

Treatment of a perforated peptic ulcer by placing a patch of biodegradable material like a “stamp” on the outside of the stomach is a feasible option.

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Acknowledgement

The authors thank Polyganics, BV (Gronigen, The Netherlands) for providing the patches and (Global Entrepreneurship Monitor) GEM (Italy) for providing the glue and Mr. G. Kors for the technical assistance.

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Authors and Affiliations

  1. Department of Plastic Surgery, Academic hospital Groningen, Hanzeplein 1, P.O. Box 30001, Groningen, 9700 RB, The Netherlands

    M. J. O. E. Bertleff & P. H. Robinson

  2. Department of Cell Biology, Section Electron Microscopy, University Groningen, The Netherlands

    R. S. B. Liem

  3. Laboratory for Animal Research, University of Groningen, The Netherlands

    H. L. Bartels

  4. Department of Plastic Surgery, Slotervaart Hospital, Amsterdam, The Netherlands

    J. F. A. Van der Werff

  5. Erasmus Medical Center Rotterdam, The Netherlands

    H. J. Bonjer

  6. Department of Surgery, Medical Center Rijnmond Zuid, Rotterdam, The Netherlands

    J. F. Lange

Authors
  1. M. J. O. E. Bertleff
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  2. R. S. B. Liem
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  3. H. L. Bartels
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  4. P. H. Robinson
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  5. J. F. A. Van der Werff
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  6. H. J. Bonjer
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  7. J. F. Lange
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Corresponding author

Correspondence to M. J. O. E. Bertleff.

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Bertleff, M., Liem, R., Bartels, H. et al. The “stamp method”: a new treatment for perforated peptic ulcer?. Surg Endosc 20, 791–793 (2006). https://doi.org/10.1007/s00464-004-2157-8

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  • DOI: https://doi.org/10.1007/s00464-004-2157-8

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