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A combination of heparin and an intermittent pneumatic compression device may be more effective to prevent deep-vein thrombosis in the lower extremities after laparoscopic cholecystectomy

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Abstract

Background

The purpose of this study was to clarify the effect of a combination of heparin and an intermittent pneumatic compression device on thrombogenesis and platelet activation in the upper and lower extremities after laparoscopy.

Methods

A blinded study was performed on 30 patients. Patients were randomly injected with either heparin or physiological saline solution (PSS) subcutaneously. The intermittent compression boot was used during surgery. Plasma D-dimer (D-D), a, marker of thrombogenesis, and β-thromboglobulin (β-TG), a marker of platelet activation, were measured in the upper and lower extremities.

Results

In the heparin group, D-Ds in the upper and lower extremities increased significantly 24 h after surgery, but they were significantly lower than those of the PSS group. β-TG in the low-r extremities of patients in the PSS group increased significantly 24 h after surgery.

Conclusion

A combination of low-molecular-weight heparin and intermittent pneumatic compression may be more effective to prevent deep-vein thrombosis in the legs.

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Authors and Affiliations

  1. Department of Anesthesiology, Dokkyo University School of Medicine, 321-0293, Mibu, Tochigi, Japan

    Y. Okuda, T. Kitajima, H. Egawa, S. Hamaguchi, S. Yamaguchi & H. Yamazaki

  2. Department of Endoscopy, Jichi Medical School, 329-0498, Minamikawach, Tochigi, Japan

    K. Ido

Authors
  1. Y. Okuda
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  2. T. Kitajima
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  3. H. Egawa
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  4. S. Hamaguchi
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  5. S. Yamaguchi
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  6. H. Yamazaki
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  7. K. Ido
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Additional information

Online publication: 8 February 2002

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Okuda, Y., Kitajima, T., Egawa, H. et al. A combination of heparin and an intermittent pneumatic compression device may be more effective to prevent deep-vein thrombosis in the lower extremities after laparoscopic cholecystectomy. Surg Endosc 16, 781–784 (2002). https://doi.org/10.1007/s00464-001-8191-x

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  • DOI: https://doi.org/10.1007/s00464-001-8191-x

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