Skip to main content
Log in

Dynamics of Capsule Swallowing by Healthy Young Men and Capsule Transit Time from the Mouth to the Stomach

  • Published:
Dysphagia Aims and scope Submit manuscript

Abstract

We examined the dynamics of capsule swallowing by healthy young men using the anterior-posterior view of videofluoroscopy as a first step in a study on capsule swallowing by dysphagic patients. The subjects were 14 healthy men who did not have any complaint of dysphagia. They were asked to swallow a #4 hard gelatin capsule filled with barium sulfate with 15 ml of water during the videofluoroscopic examination. This examination was repeated three times for each subject (total of 42 trials). In four of the 14 subjects, a swallowed capsule was retained at the upper esophageal sphincter, or the broncho-aortic constriction of the esophagus, or the lower esophageal sphincter. Except where retention occurred, the average capsule transit time from the mouth to the stomach was 6.0 ± 2.4 s. Three of the four subjects who had capsule retention did not realize that the swallowed capsule was retained en route to the stomach. By considering the dynamics of swallowing a capsule with 15 ml of water in healthy men, we should be able to reveal the dynamics of capsule swallowing in dysphagic patients, and the capsule transit time from the mouth to the stomach.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Statistics Bureau of Ministry of Internal Affairs and Communications (Japan): Census Population of 2000. Tokyo: Ministry of Internal Affairs and Communications, 2005

    Google Scholar 

  2. Statistics and Information Department, Minister’s Secretariat (Japan): Comprehensive Survey of Living Conditions of the People on Health and Welfare 2001. Tokyo: Ministry of Health, Labour and Welfare, 2003, pp 438–443

    Google Scholar 

  3. Statistics and Information Department, Minister’s Secretariat (Japan): Patient Survey 2002. Tokyo: Ministry of Health, Labour and Welfare, 2004, p 70

    Google Scholar 

  4. Gordon C, Hewer LR, Wade DT: Dysphagia in acute stroke. Br Med J 295:411–414, 1987

    CAS  Google Scholar 

  5. Horner J: Aspiration following stroke: clinical correlates and outcome. Neurology 38:1359–1362, 1988

    PubMed  CAS  Google Scholar 

  6. Daniels SK, Brailey K, Priestly DH, Herrington LR, Weisberg LA, Foundas AL: Aspiration in patients with acute stroke. Arch Phys Med Rehabil 79:14–19, 1998

    Article  PubMed  CAS  Google Scholar 

  7. Mann G, Hankey GJ, Cameron D: Swallowing function after stroke: prognosis and prognostic factors at 6 months. Stroke 30:744–748, 1999

    PubMed  CAS  Google Scholar 

  8. Yap I, Guan R, Kang JY, Gwee KA, Tan CC: Pill-induced esophageal ulcer. Singapore Med J 34:257–258, 1993

    PubMed  CAS  Google Scholar 

  9. Sugawa C, Takekuma Y, Lucas CE, Amamoto H: Bleeding esophageal ulcers caused by NSAIDs. Surg Endosc 11:143–146, 1997

    Article  PubMed  CAS  Google Scholar 

  10. Higuchi D, Sugawa C, Shab SH, Tokioka S, Lucas CE: Etiology, treatment, and outcome of esophageal ulcers: a 10-year experience in an urban emergency hospital. J Gastrointest Surg 7:836–842, 2003

    Article  PubMed  Google Scholar 

  11. Ohkuma R, Fujishima I, Kojima C, Hojo K, Takehara I, Motohashi Y: Development of a questionnaire to screen dysphagia. Jpn J Dysphagia Rehabil 6:3–8, 2002

    Google Scholar 

  12. Kei K, Yutaka M, Ichiro F: Prevalence of dysphagia among community-dwelling elderly individuals as estimated using a questionnaire for dysphagia screening. Dysphagia 19:266–271, 2004

    Google Scholar 

  13. Wright D: Medication administration in nursing homes. Nursing Standard 42:33–38, 2002

    Google Scholar 

  14. Hey H, Jorgensen F, Sorensen K, Hasselbalch H, Wamberg T: Oesophageal transit of six commonly used tablets and capsules. BMJ 285:1717–1719, 1982

    Article  PubMed  CAS  Google Scholar 

  15. Evans KT, Roberts GM: Where do all the tablets go? Lancet 4:1237–1239, 1976

    Article  Google Scholar 

  16. Robert SF, Leon SM, Gregory A, Elizabeth R, Stanley HL: Effect of bolus composition on esophageal transit: concise communication. J Nucl Med 23:878–882, 1982

    Google Scholar 

  17. Kevin SC, James PV: The effect of formulation on esophageal transit. J Pharm Pharmacol 37:126–129, 1985

    Google Scholar 

  18. Seager H: Drug-delivery products and the zydis fast-dissolving dosage form. J Pharm Pharmacol 50:357–382, 1998

    Google Scholar 

  19. Kinkendall JW, Friedman AC, Morakinyo AO, Fleischer D, Johnson LF: Pill-induced esophageal injury. Case reports and review of the medical literature. Dig Dis Sci 28:174–182, 1983

    Article  Google Scholar 

  20. Kikendall JW: Pill-induced esophageal injury. Gastroenterol Clin North Am 20:835–846, 1991

    PubMed  CAS  Google Scholar 

  21. Eng J, Sabanarhan S: Drug-induced esophagitis. Am J Gastroenterol 86:1127–1133, 1991

    PubMed  CAS  Google Scholar 

  22. Channer KS, Virjee J: The effect of size and shape of tablets on their esophageal transit. J Clin Pharmacol 26:141–146, 1986

    PubMed  CAS  Google Scholar 

  23. Channer KS, Virjee J: Effect of posture and drink volume on the swallowing of capsules. BMJ 285:1702, 1982

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hiromi Chisaka MD.

Appendix

Appendix

Appendix: Contents of Dysphagia Screening Questionnaire

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chisaka, H., Matsushima, Y., Wada, F. et al. Dynamics of Capsule Swallowing by Healthy Young Men and Capsule Transit Time from the Mouth to the Stomach. Dysphagia 21, 275–279 (2006). https://doi.org/10.1007/s00455-006-9054-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00455-006-9054-3

Keywords

Navigation