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Neuroleptic-Induced Dysphagia: Case Report and Literature Review

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Abstract

Neuroleptic medication may cause extrapyramidal symptoms (EPS) that can affect swallowing as well. This report describes a case of drug-induced dysphagia in a 53-year-old man receiving haloperidol for treatment of schizophrenia. The diagnosis was established by fiberoptic endoscopic evaluation of swallowing. After changing medication to fluphenazin, dysphagic symptoms resolved. The literature on EPS-related dysphagia, its demographic features, typical symptoms, diagnostic modalities, clinical course, and treatment options is reviewed.

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References

  1. Fioritti A, Giaccotto L, Melega V: Choking incidents among psychiatric patients: retrospective analysis of thirty-one cases from the west bologna psychiatric ward. Can J Psychiatry 42:515–520, 1997

    PubMed  CAS  Google Scholar 

  2. Hussar AE, Bragg DG: The effect of chlorpromazine on the swallowing function in chronic schizophrenic patients. Am J Psychiatry 126:152–155, 1969

    Google Scholar 

  3. Craig TJ, Richardson MA: “Cafe coronaries” in psychiatric patients. JAMA 248:2114, 1982

    Article  PubMed  CAS  Google Scholar 

  4. Bazemore PH, Tonkonogy J, Ananth R: Dysphagia in psychiatric patients: clinical and videofluoroscopic study. Dysphagia 6:2–5, 1991

    Article  PubMed  CAS  Google Scholar 

  5. Bushmann M, Dobmeyer SM, Leeker L, Perlmutter JS: Swallowing abnormalities and their responses to treatment in Parkinson’s disease. Neurology 39:1309–1314, 1989

    PubMed  CAS  Google Scholar 

  6. Gregory RP, Smith PT, Rudge P: Tardive dyskinesia presenting as severe dysphagia. J Neurol Neurosurg Psychiatry 55:1203–1204, 1992

    PubMed  CAS  Google Scholar 

  7. Langmore SE (ed.): Endoscopic evaluation and treatment of swallowing disorders. New York: Thieme, 2001

    Google Scholar 

  8. Casey DE, Keepers GA: Neuroleptic side effects: acute extrapyramidal syndromes and tardive dyskinesia. In: Casey DE, Vibeke Christensen A (eds.): Psychopharmacology: current trends. Berlin: Springer, 1988, pp 74–93

    Google Scholar 

  9. Muscettola G, Barbato G, Pampallona S, Casiello M, Bollini P: Extrapyramidal syndromes in neuroloptic-treated patients: prevalence, risk factors, and association with tardive dyskinesia. J Clin Psychopharmacol 19:203–208, 1999

    Article  PubMed  CAS  Google Scholar 

  10. Binder RL, Kazamatsuri H, Nishimura T, McNiel DE: Tardive dyskinesia and neuroleptic induced parkinsonism in Japan. Am J Psychiatry 144:1494–1496, 1987

    PubMed  CAS  Google Scholar 

  11. Richardson MA, Craig TJ: The coexistence of parkinsonism-like symptoms and tardive dyskinesia. Am J Psychiatry 139:341–343, 1982

    PubMed  CAS  Google Scholar 

  12. McCreadie RG, Robertson LJ, Wiles DH: The Nithsdale schizophrenia surveys. IX: akathisia, parkinsonism, tardive dyskinesia and plasma neuroleptic level. Br J Psychiatry 161:793–799, 1992

    Google Scholar 

  13. Miller CH, Mohr F, Umbricht D, Woerner M, Fleischhacker WW, Liebermann JA: The prevalence of acute extrapyramidal signs and symptoms in patients treated with clozapine, risperidone, and conventional antipsychotics. J Clin Psychiatry 59:69–75, 1998

    PubMed  CAS  Google Scholar 

  14. Edwards LL, Pfeiffer RF, Quigyley EMM, Hofman R, Balluf M: Gastrointestinal symptoms in Parkinson’s disease. Mov Disord 6:151–156, 1991

    Article  PubMed  CAS  Google Scholar 

  15. Sokoloff LG, Pavlakovic R: Neuroleptic-induced dysphagia. Dysphagia 12:177–179, 1997

    Article  PubMed  CAS  Google Scholar 

  16. Stewart JT: Reversible dysphagia associated with neuroleptic treatment. J Am Geriatr Soc 49:1260–1261, 2001

    Article  PubMed  CAS  Google Scholar 

  17. Stewart JT: Dysphagia associated with risperidone therapy. Dysphagia 18:274–275, 2003

    Article  PubMed  Google Scholar 

  18. Leopold NA: Dysphagia in drug-induced parkinsonism: a case report. Dysphagia 11:151–153, 1996

    Article  PubMed  CAS  Google Scholar 

  19. Hughes TAT, Shone G, Lindsay G, Wiles CM: Severe dysphagia associated with major tranquilizer treatment. Postgrad Med J 70:581–583, 1994

    Article  PubMed  CAS  Google Scholar 

  20. Bashford G, Bradd P: Drug-induced parkinsonism associated with dysphagia and aspiration: a brief report. J Geriatr Psychiatry Neurol 9:133–135, 1996

    PubMed  CAS  Google Scholar 

  21. Bulling M: Drug-induced dysphagia. Aust N Z J Med 29:748, 1999

    PubMed  CAS  Google Scholar 

  22. McCarthy RH, Terkelsen KG: Esophageal dysfunction in two patients after clozapine treatment. J Clin Psychopharmacol 14:281–283, 1994

    PubMed  CAS  Google Scholar 

  23. Sliwa JA, Lis S: Drug-induced dysphagia. Arch Phys Med Rehabil 74:445–447, 1993

    PubMed  CAS  Google Scholar 

  24. Leopold NA, Kagel MC: Pharyngo-esophageal dysphagia in Parkinson’s disease. Dysphagia 12:11–18, 1997

    Article  PubMed  CAS  Google Scholar 

  25. Leopold NA, Kagel MC: Prepharyngeal dysphagia in Parkinson’s disease. Dysphagia 11:14-22, 1996

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, University Hospital of Münster, Münster, Germany

    Rainer Dziewas MD, Tobias Warnecke MD, Martin Ritter MD, Darius G. Nabavi MD, Matthias Schilling MD & E. Bernd Ringelstein MD

  2. Westfälische Klinik Münster, Münster, Germany

    Rainer Dziewas MD, Martina Schnabel MD & Thomas Reker MD

  3. Department of Neurology, University Hospital of Münster, Albert-Schweitzer-Strasse 33, 48129, Münster, Germany

    Rainer Dziewas MD

Authors
  1. Rainer Dziewas MD
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  2. Tobias Warnecke MD
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  3. Martina Schnabel MD
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  4. Martin Ritter MD
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  5. Darius G. Nabavi MD
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  6. Matthias Schilling MD
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  7. E. Bernd Ringelstein MD
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  8. Thomas Reker MD
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Corresponding author

Correspondence to Rainer Dziewas MD.

Additional information

Rainer Dziewas and Tobias Warnecke contributed equally to this work.

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Dziewas, R., Warnecke, T., Schnabel, M. et al. Neuroleptic-Induced Dysphagia: Case Report and Literature Review. Dysphagia 22, 63–67 (2007). https://doi.org/10.1007/s00455-006-9032-9

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  • DOI: https://doi.org/10.1007/s00455-006-9032-9

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