Skip to main content

Advertisement

SpringerLink
Log in

Age-Related Remodeling of the Hypopharyngeal Constrictor Muscle and Its Subneural Apparatuses: A Scanning Electron Microscopical Study in Rats

  • Published:
Dysphagia Aims and scope Submit manuscript

Abstract

Age-related remodeling of the hypopharyngeal constrictor muscle was studied by comparing the morphological features of the subneural apparatus (SNA) of the thyropharyngeal (TP) and cricopha ryngeal (CP) muscles in young and old rats. Scanning electron microscopy revealed that the TP and CP muscles had both gutter- and depression-type SNAs, although different proportions of the two types of apparatus were found in each muscle. In young-adult rats, the gutter-type SNA was predominant in the TP muscle, whereas in the CP muscle the depression type was predominant. By contrast, in old rats, the depression-type SNA was predominant in the TP muscle, while no such transformation of the dominant SNA was noted in the CP muscle. In addition, the number of type IIb and type I muscle fibers was lower and greater, respectively, in older animals compared with those of younger animals. Furthermore, there were more type IIc fibers in the TP muscle of old rats, but no difference in the CP muscle between young and old animals. These findings suggest that the transformation of SNAs and the muscle fibers of the hypopharyngeal constrictor muscle takes place during aging and that their remodeling processes differ in the TP and CP muscles.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. JS Schindler JH Kelly (2002) ArticleTitleSwallowing disorders in the elderly Laryngoscope 112 589–602 Occurrence Handle10.1097/00005537-200204000-00001 Occurrence Handle12150508

    Article  PubMed  Google Scholar 

  2. M Hyodo R Aibara S Kawakita E Yumoto (1995) ArticleTitleHistochemical differences between the thyropharyngeal and cricopharyngeal muscles Larynx Jpn 7 64–70

    Google Scholar 

  3. M Hyodo R Aibara S Kawakita E Yumoto (1998) ArticleTitleHistochemical study of the canine inferior constrictor muscle Acta Otolaryngol 118 272–279 Occurrence Handle10.1080/00016489850155017 Occurrence Handle1:STN:280:DyaK1c3ktlWmtA%3D%3D Occurrence Handle9583798

    Article  CAS  PubMed  Google Scholar 

  4. J Lexell DY Downham (1992) ArticleTitleWhat is the effect of aging on type2 muscle fibers? J Neurol Sci 111 250–251 Occurrence Handle10.1016/0022-510X(92)90297-X

    Article  Google Scholar 

  5. R Couteaux (1958) ArticleTitleMorphological and cytochemical observations on the post-synaptic membrane at motor end-plates and ganglionic synapses Exp Cell Res 5 294–322 Occurrence Handle1:CAS:528:DyaG1MXhtFens7k%3D

    CAS  Google Scholar 

  6. HC Fertuck MM Salpeter (1974) ArticleTitleLocalization of acetylcholine receptor by 125I-labeled δ-bungarotoxin binding at mouse motor endplates Proc Natl Acad Sci USA 71 1376–1378 Occurrence Handle1:CAS:528:DyaE2cXksFynuro%3D Occurrence Handle4524643

    CAS  PubMed  Google Scholar 

  7. CW Porttor EA Barnard (1975) ArticleTitleThe density of cholinergic receptors at the endplate postsynaptic membrane: Ultrastructural studies in two mammalian species J Membr Biol 20 31–49 Occurrence Handle1121027

    PubMed  Google Scholar 

  8. MH Ellisman JE Rash LA Staelin KR Poter (1976) ArticleTitleStudies of excitable membranes. II. A comparison of specializations at neuromuscular junctions and nonjunctional sarcolemmas of mammalian fast and slow twitch muscle fibers J Cell Biol 68 752–774 Occurrence Handle10.1083/jcb.68.3.752 Occurrence Handle1:STN:280:CSiC28rjslQ%3D Occurrence Handle1030710

    Article  CAS  PubMed  Google Scholar 

  9. S Oki Y Matsuda K Kitaoka Y Nagano M Nojima J Desaki (1990) ArticleTitleScanning electron microscope study of neuromuscular junctions in different muscle fiber types in the zebra finch and rat Arch Histol Cytol 53 327–332 Occurrence Handle1:STN:280:By%2BA2Mbis1A%3D Occurrence Handle2390332

    CAS  PubMed  Google Scholar 

  10. T Yamagata S Kawakita M Hyodo J Desaki (2000) ArticleTitleScanning electron microscopic study of the neuromuscular junctions of the cricothyroid and thyroarytenoid muscles in rats Acta Otolaryngol 120 766–770 Occurrence Handle10.1080/000164800750000324 Occurrence Handle1:STN:280:DC%2BD3Mvksl2itA%3D%3D Occurrence Handle11099156

    Article  CAS  PubMed  Google Scholar 

  11. S Kawakita E Yumoto R Aibara T Yamagata J Desaki (1996) ArticleTitleNeuromuscular junctions of the posterior cricoarytenoid muscle in the adult rat: A scanning electron microscopical study Arch Histol Cytol 59 375–379 Occurrence Handle1:STN:280:ByiD1M7pslY%3D Occurrence Handle8937638

    CAS  PubMed  Google Scholar 

  12. NP Connor T Suzuki K Lee GK Sewall DM Heisey (2002) ArticleTitleNeuromuscular junction changes in aged rat thyroarytenoid muscle Ann Otol Rhinol Laryngol 111 579–586 Occurrence Handle12126012

    PubMed  Google Scholar 

  13. S Oki J Desaki T Ezaki Y Matsuda (1999) ArticleTitleAged neuromuscular junctions in the extensor digitorum longus muscle of the rats as revealed by scanning electron microscopy J Electron Microsc 48 297–300 Occurrence Handle1:STN:280:DyaK1MzlsVCrsg%3D%3D

    CAS  Google Scholar 

  14. J Desaki Y Uehara (1981) ArticleTitleThe overall morphology of neuromuscular junctions as revealed by scanning electron microscopy J Neurocytol 10 101–110 Occurrence Handle1:STN:280:Bi2D2sjhslI%3D Occurrence Handle6118394

    CAS  PubMed  Google Scholar 

  15. J Desaki Y Uehara (1987) ArticleTitleFormation and Maturation of subneural apparatuses at neuromuscular junctions in postnatal rats: A scanning and transmission electron microscopical study Dev Biol 119 390–401 Occurrence Handle1:STN:280:BiiC3cnjsVA%3D Occurrence Handle3100362

    CAS  PubMed  Google Scholar 

  16. V Dubowitz MH Brooke (1973) Muscle biopsy, A modern approach Saunders London 21–33

    Google Scholar 

  17. MH Brooke KK Kaiser (1970) ArticleTitleMuscle fiber types: How many and what kind? Arch Neurol 23 369–379 Occurrence Handle1:STN:280:CS6D38rhtlM%3D Occurrence Handle4248905

    CAS  PubMed  Google Scholar 

  18. MA Fahim JA Holley N Robbins (1983) ArticleTitleScanning and light microscopic study of age changes at neuromuscular junction in the mouse J Neurocytol 12 13–25 Occurrence Handle1:STN:280:BiyC1cfivFQ%3D Occurrence Handle6842270

    CAS  PubMed  Google Scholar 

  19. T Ogata Y Yamasaki (1985) ArticleTitleThe three-dimensional structure of motor endplates in different fiber types of rat intercostal muscle. A scanning electron-microscopic study Cell Tiss Res 241 465–472 Occurrence Handle1:STN:280:BiqB1c3lsFQ%3D

    CAS  Google Scholar 

  20. Y Matsuda S Oki K Kitaoka Y Nagano M Nojima J Desaki (1988) ArticleTitleScanning electron-microscopic study of denervated and reinnervated neuromuscular junction Muscle Nerve 11 1266–1271 Occurrence Handle1:STN:280:BiaC1c7otVI%3D Occurrence Handle3237240

    CAS  PubMed  Google Scholar 

  21. C Labrecque JP Tremblay MA Fahim (1988) ArticleTitleScanning electron microscopic study of the neuromuscular junction of dystrophic mice Exp Neurol 100 51–64 Occurrence Handle10.1016/0014-4886(88)90200-2 Occurrence Handle1:STN:280:BieC28jgsFE%3D Occurrence Handle3350097

    Article  CAS  PubMed  Google Scholar 

  22. J Desaki (1990) ArticleTitleThe morphological variability of neuromuscular junctions in the rat extraocular muscles: A scannning electron microscopical study Arch Histol Cytol 53 275–281 Occurrence Handle1:STN:280:By%2BA2MbisFw%3D Occurrence Handle2390326

    CAS  PubMed  Google Scholar 

  23. M Hyodo (1993) ArticleTitleHistochemical observations of the canine hypopharyngeal constrictor muscle J Jpn Bronchoesophagol Soc 44 405–410

    Google Scholar 

  24. Y Hisa N Tadaki T Uno H Okamura J Taguchi Y Ibata (1994) ArticleTitleCalcitonin gene-related peptide-like immunoreactive motorneurons innervating the canine inferior pharyngeal constrictor muscle Acta Otolaryngol 114 560–568 Occurrence Handle1:STN:280:ByqC38rpslY%3D Occurrence Handle7825442

    CAS  PubMed  Google Scholar 

  25. M Hyodo (1994) ArticleTitleHistochemical differentiation of the hypopharyngeal constrictor muscle J Jpn Bronchoesophagol Soc 45 234–243

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan

    Aki Taguchi, Masamitsu Hyodo, Takahiko Yamagata & Kiyofumi Gyo

  2. Department of Anatomy, Ehime University School of Medicine, Ehime, Japan

    Junzo Desaki

Authors
  1. Aki Taguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masamitsu Hyodo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takahiko Yamagata
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kiyofumi Gyo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Junzo Desaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Aki Taguchi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Taguchi, A., Hyodo, M., Yamagata, T. et al. Age-Related Remodeling of the Hypopharyngeal Constrictor Muscle and Its Subneural Apparatuses: A Scanning Electron Microscopical Study in Rats. Dysphagia 19, 241–247 (2004). https://doi.org/10.1007/s00455-004-0017-2

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00455-004-0017-2

Keywords

Search

Navigation