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Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery

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Abstract

The synthesis of modified hydrophobic starch nanoparticles using long chain fatty acids was accomplished. Grafting of fatty acid on the starch was done using potassium persulphate as catalyst and the formation of graft polymer was confirmed by FTIR spectra. The thermal properties of the native and grafted starch were investigated using simultaneous TG-DTA and DSC. The graft polymerization was found to be depending on the temperature and the duration of the reaction. The modified starch nanoparticles were cross-linked with sodium tripoly phosphate for better stabilization. Morphology of the grafted starch nanoparticles was studied by SEM and AFM. Drug-loading and the controlled release of the drug from the nanoparticles was studied using indomethacin as model drug.

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Acknowledgments

We are very grateful to Council of Scientific and Industrial Research (CSIR, India) for the financial support.

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Authors and Affiliations

  1. Chemical Sciences and Technology Division, Regional Research Laboratory (CSIR), Thiruvananthapuram, India

    C. K. Simi & T. Emilia Abraham

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  1. C. K. Simi
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  2. T. Emilia Abraham
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Correspondence to T. Emilia Abraham.

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Simi, C.K., Emilia Abraham, T. Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery. Bioprocess Biosyst Eng 30, 173–180 (2007). https://doi.org/10.1007/s00449-007-0112-5

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