Abstract
Radiation-induced apoptosis has been a topic of intense research during the last decade. Its recognition as a significant component of radiation-induced cell death has initiated several lines of investigation aimed at modulating the apoptotic response and thereby radiosensitivity. These strategies require the integration of both classical radiobiological concepts and the knowledge of the biochemical and molecular biological mechanisms involved in apoptosis induction. This review discusses mechanisms of radiation-induced apoptosis and highlights the radiobiological and radiotherapeutical relevance of this mode of cell death.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Electronic Publication
Rights and permissions
About this article
Cite this article
Verheij, M., Bartelink, H. Radiation-induced apoptosis. Cell Tissue Res 301, 133–142 (2000). https://doi.org/10.1007/s004410000188
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s004410000188