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Mitochondrial disulfide relay and its substrates: mechanisms in health and disease

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Abstract

Eukaryotic cells harbor membrane-enclosed compartments to spatially separate different biochemical processes. As a result, proteins that become synthesized in the cytosol but fulfill their function in another compartment require translocation machineries. In the intermembrane space (IMS) of mitochondria, the mitochondrial disulfide relay is responsible for the import of many soluble proteins in an oxidation-dependent manner. These IMS proteins carry out important tasks and therefore their import, folding and maintenance are crucial for the remainder of the cell. In this review, we first describe the machinery for oxidative protein folding in the IMS and then focus on recent developments, which especially concern the mammalian machinery, its substrates and its physiological role.

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Acknowledgment

Research in the author’s laboratories is supported by the German research council (DFG) to J.R. (RI2150/1-2, RI2150/2-1 (SPP1710) and SFB1218/TP B02).

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  1. Institute of Biochemistry, University of Cologne, Zuelpicher Str. 47, 50674, Cologne, Germany

    Alican J. Erdogan & Jan Riemer

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  1. Alican J. Erdogan
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  2. Jan Riemer
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Correspondence to Jan Riemer.

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This review is part of a special issue on “Recent Advances in Mitochondrial Biology - Integrated Aspects”

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Erdogan, A.J., Riemer, J. Mitochondrial disulfide relay and its substrates: mechanisms in health and disease. Cell Tissue Res 367, 59–72 (2017). https://doi.org/10.1007/s00441-016-2481-z

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