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Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies

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Abstract

The immune cell system is a critical component of host defense. Recruitment of immune cells to sites of infection, immune reaction, or injury is complex and involves coordinated adhesive interactions between the leukocyte and the endothelial cell monolayer that lines blood vessels. This article reviews basic mechanisms in the recruitment of leukocytes to tissues and then selectively reviews new concepts that are emerging based on advances in live cell imaging microscopy and mouse strains. These emerging concepts are altering the conventional paradigms of inflammatory leukocyte recruitment established in the early 1990s. Indeed, recent publications have identified previously unrecognized contributions from pericytes and interstitial leukocytes and their secreted products that guide leukocytes to their targets. Investigators have also begun to design organs on a chip. Recent reports indicate that this avenue of research holds much promise.

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Authors and Affiliations

  1. Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA 02115, USA

    Marion Leick, Veronica Azcutia, Gail Newton & Francis W. Luscinskas

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  1. Marion Leick
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  2. Veronica Azcutia
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  3. Gail Newton
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  4. Francis W. Luscinskas
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Correspondence to Francis W. Luscinskas.

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Our work was supported by funding from the NHLBI, NIH (HL-36028) and American Heart Association Postdoctoral Fellowship (11POST7730055). The project was also supported by the National Research Fund, Luxembourg and co-funded under the Marie Curie Actions of the European Commission (FP7-COFUND).

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Leick, M., Azcutia, V., Newton, G. et al. Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies. Cell Tissue Res 355, 647–656 (2014). https://doi.org/10.1007/s00441-014-1809-9

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  • DOI: https://doi.org/10.1007/s00441-014-1809-9

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