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Are TRP channels involved in sperm development and function?

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Abstract

Spermatozoa must translate information from their environment and the egg to achieve fertilization in sexually reproducing animals. These tasks require decoding a variety of signals in the form of intracellular Ca2+ changes. As TRP channels constitute a large family of versatile multi-signal transducers, they are interesting subjects in which to explore their possible participation in sperm function. Here, we review the evidence for their presence and involvement in sperm motility, maturation, and the acrosome reaction, an exocytotic process required for sperm–egg fusion. Since store-operated Ca2+ entry (SOCE) has been proposed to play an important role in these three functions, the main proteins responsible for this transport (STIM and ORAI) and their interaction with TRPs are also discussed. Improving our tools to solve infertility, improve animal breeding, and preserve biodiversity requires a better understanding of how Ca2+ is regulated in spermatozoa.

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Acknowledgements

The authors thank Andres Saralegui, Jose Luis De la Vega, Yoloxóchitl Sánchez, Shirley Ainsworth, Elizabeth Mata and Marcela Ramírez for technical assistance. We thank Juan Manuel Hurtado, Roberto Rodríguez, Orlando Trujillo Domínguez and Arturo Ocádiz for computer services. This work was supported by National Institute of Health (NIH) Grants R01 HD038082-07A1 (to AD), Consejo Nacional de Ciencia y Tecnología (CONACyT-Mexico) (99333 to CT, 84362 to ILG and 128566 to AD, CB and CT; Dirección General de Asuntos del Personal Académico/ Universidad Nacional Autónoma de México (DGAPA/ UNAM) (IN225406 to AD, IN217409 and IN204112-3 to CB, IN217210 to ILG and IN202212-3 to CT).

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Authors and Affiliations

  1. Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología-Universidad Nacional Autónoma de México, 62210, Cuernavaca, México

    Alberto Darszon, Claudia Sánchez-Cárdenas, Gerardo Orta, Ana A. Sánchez-Tusie, Carmen Beltrán, Ignacio López-González & Claudia L. Treviño

  2. Facultad de Ciencias. Universidad Autónoma del Estado de México, Toluca Edo. de México, CP 50000, Cuernavaca, México

    Gisela Granados-González

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  1. Alberto Darszon
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  2. Claudia Sánchez-Cárdenas
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  3. Gerardo Orta
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  4. Ana A. Sánchez-Tusie
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  5. Carmen Beltrán
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  6. Ignacio López-González
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  7. Gisela Granados-González
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  8. Claudia L. Treviño
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Correspondence to Alberto Darszon.

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Darszon, A., Sánchez-Cárdenas, C., Orta, G. et al. Are TRP channels involved in sperm development and function?. Cell Tissue Res 349, 749–764 (2012). https://doi.org/10.1007/s00441-012-1397-5

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  • DOI: https://doi.org/10.1007/s00441-012-1397-5

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