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How reggies regulate regeneration and axon growth

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Abstract

The microdomain-forming proteins reggie-1 and reggie-2 (alias flotillins) were found to be upregulated in axon-regenerating fish retinal ganglion cells (RGCs). They were subsequently shown to be indispensible for axon regeneration and neurite extension in fish and mammals. Our current concept proposes that reggies—often together with the cellular Prion protein (PrP)—regulate the turnover of membrane and specific membrane proteins at the growth cone, which is the prerequisite for neurite elongation and guidance.

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  1. Department of Biology, University of Konstanz, 78467, Konstanz, Germany

    Claudia A. O. Stuermer

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Correspondence to Claudia A. O. Stuermer.

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Stuermer, C.A.O. How reggies regulate regeneration and axon growth. Cell Tissue Res 349, 71–77 (2012). https://doi.org/10.1007/s00441-012-1343-6

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