Skip to main content

Advertisement

SpringerLink
Log in

Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questions

  • Minireview
  • Published:
Cell and Tissue Research Aims and scope Submit manuscript

Abstract

Adult mesenchymal stem cells (MSCs) have the capacity for self-renewal and for differentiating into a variety of cells and tissues. They may leave their niche to migrate to remote tissues and play a critical role in wound repair and tissue regeneration. Because of their multipotency, easy isolation and culture, highly expansive potential, and immunosuppression properties, these cells may be an attractive therapeutic tool for regenerative medicine and tissue engineering. Several studies have indicated a contribution of MSCs to reconstituting skin in cutaneous wounds, but problems still need resolution before MSCs can be widely used clinically. This review focuses mainly on the benefits of MSCs in skin wound healing and tissue regeneration and on the questions that remain to be answered before MSCs can be used in clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Arinzeh TL, Peter SJ, Archambault MP, Bos C van den, Gordon S, Kraus K, Smith A, Kadiyala S (2003) Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect. J Bone Joint Surg Am 85-A:1927–1935

    PubMed  Google Scholar 

  • Altincicek B, Vilcinskas A (2008) Comparative analysis of septic injury-inducible genes in phylogenetically distant model organisms of regeneration and stem cell research, the planarian Schmidtea mediterranea and the cnidarian Hydra vulgaris. Front Zool 5:6

    Article  PubMed  CAS  Google Scholar 

  • Badiavas EV, Abedi M, Butmarc J, Falanga V, Quesenberry P (2003) Participation of bone marrow derived cells in cutaneous wound healing. J Cell Physiol 196:245–250

    Article  PubMed  CAS  Google Scholar 

  • Bajada S, Mazakova I, Richardson JB, Ashammakhi N (2008) Updates on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med 2:169–183

    Article  PubMed  CAS  Google Scholar 

  • Baksh D, Song L, Tuan RS (2004) Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 8:301–316

    Article  PubMed  CAS  Google Scholar 

  • Barry FP (2003) Mesenchymal stem cell therapy in joint disease. Novartis Found Symp 249:86–96

    Article  PubMed  Google Scholar 

  • Clark LD, Clark RK, Heber-Katz E (1998) A new murine model for mammalian wound repair and regeneration. Clin Immunol Immunopathol 88:35–45

    Article  PubMed  CAS  Google Scholar 

  • Crevensten G, Walsh AJ, Ananthakrishnan D, Page P, Wahba GM, Lotz JC, Berven S (2004) Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs. Ann Biomed Eng 32:430–434

    Article  PubMed  Google Scholar 

  • Dai Y, Li J, Li J, Dai G, Mu H, Wu Q, Hu K, Cao Q (2007) Skin epithelial cells in mice from umbilical cord blood mesenchymal stem cells. Burns 33:418–428

    Article  PubMed  Google Scholar 

  • Elwood D, Pomposelli JJ (2006) Hepatobiliary surgery: lessons learned from live donor hepatectomy. Surg Clin North Am 86:1207–1217

    Article  PubMed  Google Scholar 

  • Davenport RJ (2005) What controls organ regeneration? Science 309:84

    Article  PubMed  CAS  Google Scholar 

  • Deng W, Han Q, Liao L, Li C, Ge W, Zhao Z, You S, Deng H, Murad F, Zhao RC (2005) Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue. Tissue Eng 11:110–119

    Article  PubMed  CAS  Google Scholar 

  • Fu XB, Shen ZY, Cheng YL, Xin JH, Zhang ML, Guo ZR, Sheng ZY (1998) Randomized placebo controlled trial of use of topical recombinant bovine basic fibroblast growth factor for second-degree burns. Lancet 352:1661–1664

    Article  PubMed  CAS  Google Scholar 

  • Fu XB, Shen ZY, Chen YL, He JH, Guo ZR, Zhang ML, Sheng ZY (2000) Recombinant bovine basic fibroblast growth factor accelerates wound healing in patients with burns, donor sites and chronic dermal ulcers. Chin Med J 113:367–371

    PubMed  CAS  Google Scholar 

  • Fu XB, Li XK, Cheng B, Chen W, Sheng ZY (2005) Engineered growth factors and cutaneous wound healing: success and possible questions in the past 10 years. Wound Rep Reg 13:122–130

    Article  Google Scholar 

  • Fu XB, Fang LJ, Li XK, Cheng B, Sheng ZY (2006a) Enhanced wound-healing quality with bone marrow mesenchymal stem cells autografting after skin injury. Wound Rep Reg 14:325–335

    Article  Google Scholar 

  • Fu XB, Qu ZL, Sheng ZY (2006b) Potentiality of mesenchymal stem cells in regeneration of sweat glands. J Surg Res 136:204–208

    Article  PubMed  Google Scholar 

  • Fukuda K (2002) Molecular characterization of regenerated cardiomyocytes derived from adult mesenchymal stem cells. Congenit Anom Kyoto 42:1–9

    Article  PubMed  CAS  Google Scholar 

  • Jones EA, Kinsey SE, English A, Jones RA, Straszynski L, Meredith DM, Markham AF, Jack A, Emery P, McGonagle D (2002) Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 46:3349–3360

    Article  PubMed  Google Scholar 

  • Kataoka K, Medina RJ, Kageyama T, Miyazaki M, Yoshino T, Makino T, Huh NH (2003) Participation of adult mouse bone marrow cells in reconstitution of skin. Am J Pathol 163:1227–1231

    PubMed  Google Scholar 

  • Kim WS, Park BS, Sung JH, Yang JM, Park SB, Kwak SJ, Park JS (2007) Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci 48:15–24

    Article  PubMed  CAS  Google Scholar 

  • Lataillade JJ, Doucet C, Bey E, Carsin H, Huet C, Clairand I, Bottollier-Depois JF, Chapel A, Ernou I, Gourven M, Boutin L, Hayden A, Carcamo C, Buglova E, Joussemet M, Revel T de, Gourmelon P (2007) New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regen Med 2:785–794

    Article  PubMed  CAS  Google Scholar 

  • Li HH, Fu XB, Ouyang YS, Cai CL, Wang J, Sun TZ (2006) Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages. Cell Tissue Res 14:325–335

    Google Scholar 

  • Liu H, Kemeny DM, Heng BC, Ouyang HW, Melendez AJ, Cao T (2006) The immunogenicity and immunomodulatory function of osteogenic cells differentiated from mesenchymal stem cells. J Immunol 176:2864–2871

    PubMed  CAS  Google Scholar 

  • Mansilla E, Marin GH, Sturla M, Drago HE, Gil MA, Salas E, Gardiner MC, Piccinelli G, Bossi S, Salas E, Petrelli L, Iorio G, Ramos CA, Soratti C (2005) Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injures. Transplant Proc 37:292–294

    Article  PubMed  CAS  Google Scholar 

  • Nogi T, Levin M (2005) Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration. Dev Biol 287:314–335

    Article  PubMed  CAS  Google Scholar 

  • Ortiz LA, Gambelli F, McBride C, Gaupp D, Baddoo M, Kaminski N, Phinney DG (2003) Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA 100:8407–8411

    Article  PubMed  CAS  Google Scholar 

  • Perng CK, Ku HH, Chiou SH, Chen IL, Tsai FT, Yang YP, Chang KY, Kao CL (2006) Evaluation of wound healing effect on skin-defect nude mice by using human dermis-derived mesenchymal stem cells. Transplant Proc 38:3086–3087

    Article  PubMed  CAS  Google Scholar 

  • Sasaki M, Abe R, Fujita Y, Ando S, Inokuma D, Shimizu H (2008) Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type. J Immunol 180:2581–2587

    PubMed  CAS  Google Scholar 

  • Shih DT, Lee DC, Chen SC, Tsai RY, Huang CT, Tsai CC, Shen EY, Chiu WT (2005) Isolation and characterization of neurogenic mesenchymal stem cells in human scalp tissue. Stem Cells 23:1012–1020

    Article  PubMed  CAS  Google Scholar 

  • Shumakov VI, Onishchenko NA, Rasulov MF, Krasheninnikov ME, Zaidenov VA (2003) Mesenchymal bone marrow stem cells more effectively stimulate regeneration of deep burn wounds than embryonic fibroblasts. Bull Exp Biol Med 136:192–195

    Article  PubMed  CAS  Google Scholar 

  • Spees JL, Olson SD, Ylostalo J, Lynch PJ, Smith J, Perry A, Peister A, Wang MY, Prockop DJ (2003) Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma. Proc Natl Acad Sci USA 100:2397–2402

    Article  PubMed  CAS  Google Scholar 

  • Stocum DL (2004) Tissue restoration through regenerative biology and medicine. Adv Anat Embryol Cell Biol 176:1–101

    Google Scholar 

  • Tsonis PA, Madhavan M, Tancous EE, Del Rio-Tsonis K (2004) A newt’s eye view of lens regeneration. Int J Dev Biol 48:975–980

    Article  PubMed  Google Scholar 

  • Tuan RS, Boland G, Tuli R (2003) Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther 5:32–45

    Article  PubMed  CAS  Google Scholar 

  • Wu Y, Chen L, Scott PG, Tredget EE (2007) Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 25:2648–2659

    Article  PubMed  CAS  Google Scholar 

  • Vojtassák J, Danisovic L, Kubes M, Bakos D, Jarábek L, Ulicná M, Blasko M (2006) Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot. Neuroendocrinol Lett 27 (Suppl 2):134–137

    PubMed  Google Scholar 

  • Yamada Y, Nishimoto E, Mitsuya H, Yonemura Y (2006) In vitro transdifferentiation of adult bone marrow Sca-1+ cKit− cells cocultured with fetal liver cells into hepatic-like cells without fusion. Exp Hematol 34:97–106

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa T, Mitsuno H, Nonaka I, Sen Y, Kawanishi K, Inada Y, Takakura Y, Okuchi K, Nonomura A (2008) Wound therapy by marrow mesenchymal cell transplantation. Plast Reconstr Surg 121:860–877

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest statement

The authors declare that they have no competing financial interests.

Author information

Authors and Affiliations

  1. Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical College, General Hospital of PLA, 28 Fu Xing Road, Beijing, 100853, P. R. China

    Xiaobing Fu

  2. Shantou University Medical College, GuangDong Province, Shantou, 515063, P. R. China

    Haihong Li

Authors
  1. Xiaobing Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Haihong Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiaobing Fu.

Additional information

This study was supported in part by the National Natural Science Foundation of China (30730090, 30672176, 30500194) and by State Key Development Program of Basic Research of China (973 Program, 2005CB522603).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fu, X., Li, H. Mesenchymal stem cells and skin wound repair and regeneration: possibilities and questions. Cell Tissue Res 335, 317–321 (2009). https://doi.org/10.1007/s00441-008-0724-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00441-008-0724-3

Keywords

Search

Navigation