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Wnt signaling and neural stem cells: caught in the Wnt web

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Abstract

Wnt proteins have now been identified as major physiological regulators of multiple aspects of stem cell biology, from self-renewal and pluripotency to precursor cell competence and terminal differentiation. Neural stem cells are the cellular building blocks of the developing nervous system and provide the basis for continued neurogenesis in the adult mammalian central nervous system. Here, we outline the most recent advances in the field about the critical factors and regulatory networks involved in Wnt signaling and discuss recent findings on how this increasingly intricate pathway contributes to the shaping of the developing and adult nervous system on the level of the neural stem cell.

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  1. Theologos M. Michaelidis

    Present address: Foundation for Research & Technology-Hellas, Biomedical Research Institute, University of Ioannina, Science and Technology School, 45110, Ioannina, Greece

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  1. GSF-National Research Center for Environment and Health, Institute of Developmental Genetics, Ingolstädter Landstrasse 1, 85764, Munich-Neuherberg, Germany

    Theologos M. Michaelidis & D. Chichung Lie

  2. Department of Biological Applications & Technology, University of Ioannina, Science and Technology School, 45110, Ioannina, Greece

    Theologos M. Michaelidis

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We wish to apologize to those whose work is not included due to the length constraints on the review. Work in the Lie lab is supported by the European Young Investigator Award Program of the European Science Foundation and grants of the Deutsche Forchungsgemeinschaft (LI 858/5-1), the European Union (Marie Curie Excellence Team Award and Marie Curie International Reintegration Grant), and the Bavarian Research Network “Adult Neural Stem Cells” FORNEUROCELL.

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Michaelidis, T.M., Lie, D.C. Wnt signaling and neural stem cells: caught in the Wnt web. Cell Tissue Res 331, 193–210 (2008). https://doi.org/10.1007/s00441-007-0476-5

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