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Capsaicin receptor expression in the rat temporomandibular joint

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Abstract

Experimentally, temporomandibular joint (TMJ) nerve units respond to capsaicin, which is used clinically to treat TMJ pain. However, the existence of capsaicin receptors in the TMJ has not previously been clearly demonstrated. Immunohistochemical analysis has revealed the presence of transient receptor potential vanilloid subtype 1 (TRPV1) expression in the nerves and synovial lining cells of the TMJ. TRPV1-immunoreactive nerves are distributed in the synovial membrane of the joint capsule and provide branches to the joint compartment. The disc periphery is supplied by TRPV1 nerves that are mostly associated with small arterioles, and occasional nerves penetrate to the synovial lining layer. Double immunofluorescence has shown that many TRPV1-immunoreactive nerves are labeled with neuropeptide calcitonin gene-related peptide, whereas few are labeled with IB4-lectin. The results provide evidence for the presence of TRPV1 in both nerves and synovial lining cells, which might thus be involved in the mechanism of nociception and inflammation in the TMJ.

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Acknowledgement

We appreciate the advice and expertise of T. Kondo.

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Authors and Affiliations

  1. Department of Orthodontics, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan

    Hideki Ioi, Shunsuke Nakata & Akihiko Nakasima

  2. Department of Anatomy and Cell Biology, Graduate School of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Mizuho A. Kido, Jing-Qi Zhang, Takayoshi Yamaza & Teruo Tanaka

Authors
  1. Hideki Ioi
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  2. Mizuho A. Kido
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  3. Jing-Qi Zhang
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  4. Takayoshi Yamaza
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  5. Shunsuke Nakata
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  6. Akihiko Nakasima
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  7. Teruo Tanaka
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Corresponding author

Correspondence to Mizuho A. Kido.

Additional information

This study was supported by a grant-in-aid for Scientific Research (C), no. 15591938, from the Japanese Ministry of Education, Science, Sports, Culture, and Technology (to M.A.K.).

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Ioi, H., Kido, M.A., Zhang, JQ. et al. Capsaicin receptor expression in the rat temporomandibular joint. Cell Tissue Res 325, 47–54 (2006). https://doi.org/10.1007/s00441-006-0183-7

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  • DOI: https://doi.org/10.1007/s00441-006-0183-7

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