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Stem cell therapy for Parkinson’s disease: where do we stand?

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Abstract

A major neuropathological feature of Parkinson’s disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.

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Acknowledgment

We thank Emma Lane for critical reading of the manuscript.

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Authors and Affiliations

  1. Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, BMC A10, 221 84, Lund, Sweden

    Laurent Roybon, Nicolaj S. Christophersen, Patrik Brundin & Jia-Yi Li

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  1. Laurent Roybon
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  2. Nicolaj S. Christophersen
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  3. Patrik Brundin
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  4. Jia-Yi Li
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Corresponding author

Correspondence to Laurent Roybon.

Additional information

Our work described in this article was supported by the National Institute of Health, USA, the Swedish Research Council, the Swedish Parkinson’s Disease Foundation, the Syskonen Svenssons Foundation, an USAMRMC grant, and an ATV grant

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Roybon, L., Christophersen, N.S., Brundin, P. et al. Stem cell therapy for Parkinson’s disease: where do we stand?. Cell Tissue Res 318, 261–273 (2004). https://doi.org/10.1007/s00441-004-0946-y

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  • DOI: https://doi.org/10.1007/s00441-004-0946-y

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