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Forging the endothelium during inflammation: pushing at a half-open door?

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Abstract

During an inflammatory response, changes in the adhesive properties of the endothelium occur that enable normally non-adherent blood-borne leukocytes to adhere and subsequently to traverse the endothelium through small gaps at inter-cellular junctions. This review concentrates on the role played by inter-endothelial adhesion molecules during transmigration and the way in which their expression may be regulated during inflammation. We show that the final "open" signals that lead to the formation of clefts between adjacent endothelial cells may be derived from inflamed tissue underlying the endothelium and from activated leukocytes.

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References

  • Ager A (1994) Lymphocyte recirculation and homing: roles of adhesion molecules and chemoattractants. Trends Cell Biol 4:326–333

    Article  CAS  Google Scholar 

  • Ager A (2003) Inflammation: border crossings. Nature 421:703–705

    Article  CAS  PubMed  Google Scholar 

  • Akira S, Takeda K, Kaisho T (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2:675–680

    CAS  PubMed  Google Scholar 

  • Allport JR, Muller WA, Luscinskas FW (2000) Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow. J Cell Biol 148:203–216

    Article  CAS  PubMed  Google Scholar 

  • Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA (1995) The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 128:1243–1253

    CAS  PubMed  Google Scholar 

  • Anderson AO, Anderson ND (1976) Lymphocyte emigration from high endothelial venules in rat lymph nodes. Immunology 31:731–748

    CAS  PubMed  Google Scholar 

  • Anderson ND, Anderson AO, Wyllie RG (1976) Specialized structure and metabolic activities of high endothelial venules in rat lymphatic tissues. Immunology 31:455–473

    CAS  PubMed  Google Scholar 

  • Arrate MP, Rodriguez JM, Tran TM, Brock TA, Cunningham SA (2001) Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. J Biol Chem 276:45826–45832

    Article  CAS  PubMed  Google Scholar 

  • Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B (1990) CD44 is the principal cell surface receptor for hyaluronate. Cell 61:1303–1313

    PubMed  Google Scholar 

  • Aurrand-Lions MA, Duncan L, Du Pasquier L, Imhof BA (2000) Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family? Curr Top Microbiol Immunol 251:91–98

    CAS  PubMed  Google Scholar 

  • Aurrand-Lions MA, Duncan L, Ballestrem C, Imhof BA (2001) JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells. J Biol Chem 276:2733–2741

    Article  CAS  PubMed  Google Scholar 

  • Aurrand-Lions M, Johnson-Leger C, Imhof BA (2002) The last molecular fortress in leukocyte trans-endothelial migration. Nat Immunol 3:116–118

    Article  CAS  PubMed  Google Scholar 

  • Ayalon O, Sabanai H, Lampugnani MG, Dejana E, Geiger B (1994) Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. J Cell Biol 126:247–258

    CAS  PubMed  Google Scholar 

  • Baekkevold ES, Yamanaka T, Palframan RT, Carlsen HS, Reinholt FP, Andrian UH von, Brandtzaeg P, Haraldsen G (2001) The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J Exp Med 193:1105–1112

    Article  CAS  PubMed  Google Scholar 

  • Baggiolini M, Dahinden CA (1994) CC chemokines in allergic inflammation. Immunol Today 15:127–133

    CAS  Google Scholar 

  • Baluk P, Hirata A, Thurston G, Fujiwara T, Neal CR, Michel CC, McDonald DM (1997) Endothelial gaps: time course of formation and closure in inflamed venules of rats. Am J Physiol 272:L155–L170

    CAS  PubMed  Google Scholar 

  • Bazzoni G, Martinez-Estrada OM, Orsenigo F, Cordenonsi M, Citi S, Dejana E (2000) Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin. J Biol Chem 275:20520–20526

    Article  CAS  PubMed  Google Scholar 

  • Ben-Baruch A, Michiel DF, Oppenheim JJ (1995) Signals and receptors involved in recruitment of inflammatory cells. J Biol Chem 270:11703–11706

    CAS  PubMed  Google Scholar 

  • Berg EL, Goldstein LA, Jutila MA, Nakache M, Picker PR, Streeter NW, Wu NW, Zhou D, Butcher EC (1989) Homing receptors and vascular addressins: cell adhesion molecules that direct lymphocyte traffic. Immunol Rev 108:5-18

    CAS  Google Scholar 

  • Berlin C, Bargatze RF, Campbell JJ, Andrian UH von, Szabo MC, Hasslen SR, Nelson RD, Berg EL, Erlandsen SL, Butcher EC (1995) Alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80:413–422

    CAS  PubMed  Google Scholar 

  • Beyer EC (1993) Gap junctions. Int Rev Cytol:1–37

    Google Scholar 

  • Bianchi E, Bender JR, Blasi F, Pardi R (1997) Through and beyond the wall: late steps in leukocyte transendothelial migration. Immunol Today 18:586–591

    Article  CAS  PubMed  Google Scholar 

  • Bird IN, Taylor V, Newton JP, Spragg JH, Simmons DL, Salmon M, Buckley CD (1999) Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration. J Cell Sci 112:1989–1997

    CAS  PubMed  Google Scholar 

  • Bogen S, Pak J, Garifallou M, Deng X, Muller WA (1994) Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. J Exp Med 179:1059–1064

    CAS  PubMed  Google Scholar 

  • Bruzzone R, Haefliger JA, Gimlich RL, Paul DL (1993) Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins. Mol Biol Cell 4:7-20

    CAS  PubMed  Google Scholar 

  • Burns AR, Walker DC, Brown ES, Thurmon LT, Bowden RA, Keese CR, Simon SI, Entman ML, Smith CW (1997) Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners. J Immunol 159:2893–2903

    CAS  PubMed  Google Scholar 

  • Burns AR, Bowden RA, MacDonell SD, Walker DC, Odebunmi TO, Donnachie EM, Simon SI, Entman ML, Smith CW (2000) Analysis of tight junctions during neutrophil transendothelial migration. J Cell Sci 113:45–57

    CAS  PubMed  Google Scholar 

  • Butcher EC, Picker LJ (1996) Lymphocyte homing and homeostasis. Science 272:60–66

    Google Scholar 

  • Carlos TM, Harlan JM (1994) Leukocyte-endothelial adhesion molecules. Blood 84:2068–2101

    CAS  PubMed  Google Scholar 

  • Clark RA, Alon R, Springer TA (1996) CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma. J Cell Biol 134:1075–1087

    PubMed  Google Scholar 

  • Corada M, Mariotti M, Thurston G, Smith K, Kunkel R, Brockhaus M, Lampugnani MG, Martin-Padura I, Stoppacciaro A, Ruco L, et al (1999) Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci USA 96:9815–9820

    CAS  PubMed  Google Scholar 

  • Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (2000) A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions. J Biol Chem 275:34750–34756

    Article  CAS  PubMed  Google Scholar 

  • Dangerfield J, Larbi KY, Huang MT, Dewar A, Nourshargh S (2002) PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane. J Exp Med 196:1201–1211

    Article  CAS  PubMed  Google Scholar 

  • Dawson J, Sedgwick AD, Edwards JC, Lees P (1992) The monoclonal antibody MEL-14 can block lymphocyte migration into a site of chronic inflammation. Eur J Immunol 22:1647–1650

    CAS  PubMed  Google Scholar 

  • DeGrendele HC, Estess P, Picker LJ, Siegelman MH (1996) CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway. J Exp Med 183:1119–1130

    PubMed  Google Scholar 

  • DeGrendele HC, Kosfiszer M, Estess P, Siegelman MH (1997) CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation. J Immunol 159:2549–2553

    CAS  PubMed  Google Scholar 

  • Dejana E, Del Maschio A (1995) Molecular organization and functional regulation of cell to cell junctions in the endothelium. Thromb Haemost 74:309–312

    CAS  PubMed  Google Scholar 

  • Dejana E, Corada M, Lampugnani MG (1995) Endothelial cell-to-cell junctions. FASEB J 9:910–918

    PubMed  Google Scholar 

  • Dejana E, Zanetti A, Del Maschio A (1996) Adhesive proteins at endothelial cell-to-cell junctions and leukocyte extravasation. Haemostasis 26 (Suppl 4):210–219

    CAS  Google Scholar 

  • Dejana E, Valiron O, Navarro P, Lampugnani MG (1997) Intercellular junctions in the endothelium and the control of vascular permeability. Ann N Y Acad Sci 811:36–43

    CAS  PubMed  Google Scholar 

  • Del Maschio A, Zanetti A, Corada M, Rival Y, Ruco L, Lampugnani MG, Dejana E (1996) Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions. J Cell Biol 135:497–510

    PubMed  Google Scholar 

  • DeLisser HM, Newman PJ, Albelda SM (1994) Molecular and functional aspects of PECAM-1/CD31. J Cell Biol 100:100–110

    Google Scholar 

  • Diacovo TG, Puri KD, Warnock RA, Springer TA, Andrian UH von (1996a) Platelet-mediated lymphocyte delivery to high endothelial venules. Science 273:252–255

    CAS  PubMed  Google Scholar 

  • Diacovo TG, Roth SJ, Buccola JM, Bainton DF, Springer TA (1996b) Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood 88:146–157

    CAS  PubMed  Google Scholar 

  • Diacovo TG, Catalina MD, Siegelman MH, Andrian UH von (1998) Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice. J Exp Med 187:197–204

    Article  CAS  PubMed  Google Scholar 

  • Doukas J, Pober JS (1990) IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1. J Immunol 145:1727–1733

    CAS  PubMed  Google Scholar 

  • Duijvestijn AM, Kerkhove M, Bargatze RF, Butcher EC (1987) Lymphoid tissue- and inflammation-specific endothelial cell differentiation defined by monoclonal antibodies. J Immunol 138:713–719

    CAS  PubMed  Google Scholar 

  • Duncan GS, Andrew DP, Takimoto H, Kaufman SA, Yoshida H, Spellberg J, Luis de la Pompa J, Elia A, Wakeham A, Karan-Tamir B, et al (1999) Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol 162:3022–3030

    CAS  PubMed  Google Scholar 

  • Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA (1986) Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 137:245–254

    CAS  PubMed  Google Scholar 

  • Ebnet K, Schulz CU, Meyer Zu Brickwedde MK, Pendl GG, Vestweber D (2000) Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. J Biol Chem 275:27979–27988

    CAS  PubMed  Google Scholar 

  • Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D (2001) The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J 20:3738–3748

    Article  CAS  PubMed  Google Scholar 

  • Esser S, Lampugnani MG, Corada M, Dejana E, Risau W (1998) Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci 111:1853–1865

    CAS  PubMed  Google Scholar 

  • Feng D, Nagy JA, Pyne K, Dvorak HF, Dvorak AM (1998) Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J Exp Med 187:903–915

    Article  CAS  PubMed  Google Scholar 

  • Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S (1993) Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 123:1777–1788

    CAS  PubMed  Google Scholar 

  • Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S (1998) Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 141:1539–1550

    CAS  PubMed  Google Scholar 

  • Fuster V, Badimon L, Badimon JJ, Chesebro JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med 326:242–250

    Google Scholar 

  • Gal I, Lesley J, Ko W, Gonda A, Stoop R, Hyman R, Mikecz K (2003) Role of the extracellular and cytoplasmic domains of CD44 in the rolling interaction of lymphoid cells with hyaluronan under physiologic flow. J Biol Chem 278:11150–11158

    Article  CAS  PubMed  Google Scholar 

  • Geiger B, Ayalon O (1992) Cadherins. Annu Rev Cell Biol 8:307–332

    CAS  PubMed  Google Scholar 

  • Ginsberg MH, Du X, Plow EF (1992) Inside-out integrin signalling. Curr Opin Cell Biol 4:766–771

    Google Scholar 

  • Girard JP, Springer TA (1995) High endothelial venules (HEV): specialized endothelium for lymphocyte migration. Immunol Today 16:449–457

    Google Scholar 

  • Girard JP, Baekkevold ES, Yamanaka T, Haraldsen G, Brandtzaeg P, Amalric F (1999) Heterogeneity of endothelial cells: the specialized phenotype of human high endothelial venules characterized by suppression subtractive hybridization. Am J Pathol 155:2043–2055

    CAS  PubMed  Google Scholar 

  • Goeckeler ZM, Wysolmerski RB (1995) Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J Cell Biol 130:613–627

    CAS  PubMed  Google Scholar 

  • Gumbiner BM (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84:345–357

    CAS  PubMed  Google Scholar 

  • Hafezi-Moghadam A, Thomas KL, Prorock AJ, Huo Y, Ley K (2001) L-selectin shedding regulates leukocyte recruitment. J Exp Med 193:863–872

    Article  CAS  PubMed  Google Scholar 

  • Hagberg IA, Roald HE, Lyberg T (1998) Adhesion of leukocytes to growing arterial thrombi. Thromb Haemost 80:852–858

    CAS  PubMed  Google Scholar 

  • Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ (1989) Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J Biol Chem 264:7768–7771

    CAS  PubMed  Google Scholar 

  • Henderson RB, Lim LH, Tessier PA, Gavins FN, Mathies M, Perretti M, Hogg N (2001) The use of lymphocyte function-associated antigen (LFA)-1-deficient mice to determine the role of LFA-1, Mac-1, and alpha4 integrin in the inflammatory response of neutrophils. J Exp Med 194:219–226

    Article  CAS  PubMed  Google Scholar 

  • Hinsbergh VW van, Nieuw Amerongen GP van (2002) Intracellular signalling involved in modulating human endothelial barrier function. J Anat 200:549–560

    Article  PubMed  Google Scholar 

  • Hirata A, Baluk P, Fujiwara T, McDonald DM (1995) Location of focal silver staining at endothelial gaps in inflamed venules examined by scanning electron microscopy. Am J Physiol 269:L403–L418

    CAS  PubMed  Google Scholar 

  • Hixenbaugh EA, Goeckeler ZM, Papaiya NN, Wysolmerski RB, Silverstein SC, Huang AJ (1997) Stimulated neutrophils induce myosin light chain phosphorylation and isometric tension in endothelial cells. Am J Physiol 273:H981–H988

    CAS  PubMed  Google Scholar 

  • Hordijk PL, Anthony E, Mul FP, Rientsma R, Oomen LC, Roos D (1999) Vascular-endothelial-cadherin modulates endothelial monolayer permeability. J Cell Sci 112:1915–1923

    PubMed  Google Scholar 

  • Hu MC, Holzmann B, Crowe DT, Neuhaus H, Weissman IL (1993) The Peyer's patch homing receptor. Curr Top Microbiol Immunol 184:125–138

    CAS  PubMed  Google Scholar 

  • Huang AJ, Furie MB, Nicholson SC, Fischbarg J, Liebovitch LS, Silverstein SC (1988) Effects of human neutrophil chemotaxis across human endothelial cell monolayers on the permeability of these monolayers to ions and macromolecules. J Cell Physiol 135:355–366

    CAS  PubMed  Google Scholar 

  • Huang AJ, Manning JE, Bandak TM, Ratau MC, Hanser KR, Silverstein SC (1993) Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J Cell Biol 120:1371–1380

    CAS  PubMed  Google Scholar 

  • Jara PI, Boric MP, Saez JC (1995) Leukocytes express connexin 43 after activation with lipopolysaccharide and appear to form gap junctions with endothelial cells after ischemia-reperfusion. Proc Natl Acad Sci USA 92:7011–7015

    CAS  PubMed  Google Scholar 

  • Johnson-Leger C, Aurrand-Lions M, Imhof BA (2000) The parting of the endothelium: miracle, or simply a junctional affair? J Cell Sci 113:921–933

    CAS  PubMed  Google Scholar 

  • Johnson-Leger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (2002) Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood 100:2479–2486

    Article  CAS  PubMed  Google Scholar 

  • Kemler R (1993) From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 9:317–321

    CAS  PubMed  Google Scholar 

  • Kooyk Y van, Weder P, Heije K, Figdor CG (1994) Extracellular Ca2+ modulates leukocyte function-associated antigen-1 cell surface distribution on T lymphocytes and consequently affects cell adhesion. J Cell Biol 124:1061–1070

    PubMed  Google Scholar 

  • Kornecki E, Walkowiak B, Naik UP, Ehrlich YH (1990) Activation of human platelets by a stimulatory monoclonal antibody. J Biol Chem 265:10042–10048

    CAS  PubMed  Google Scholar 

  • Kucik DF, Dustin ML, Miller JM, Brown EJ (1996) Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes. J Clin Invest 97:2139–2144

    CAS  PubMed  Google Scholar 

  • Kuijper PH, Gallardo Torres HI, Lammers JW, Sixma JJ, Koenderman L, Zwaginga JJ (1997) Platelet and fibrin deposition at the damaged vessel wall: cooperative substrates for neutrophil adhesion under flow conditions. Blood 89:166–175

    CAS  PubMed  Google Scholar 

  • Lalor P, Nash GB (1995) Adhesion of flowing leucocytes to immobilized platelets. Br J Haematol 89:725–732

    CAS  PubMed  Google Scholar 

  • Lampugnani MG, Resnati M, Raiteri M, Pigott R, Pisacane A, Houen G, Ruco LP, Dejana E (1992) A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J Cell Biol 118:1511–1522

    CAS  PubMed  Google Scholar 

  • Larson DM, Wrobleski MJ, Sagar GD, Westphale EM, Beyer EC (1997) Differential regulation of connexin43 and connexin37 in endothelial cells by cell density, growth, and TGF-beta1. Am J Physiol 272:C405–C415

    CAS  PubMed  Google Scholar 

  • Larson RS, Springer TA (1990) Structure and function of leukocyte integrins. Immunol Rev 114:181–217

    CAS  PubMed  Google Scholar 

  • Lasky LA (1995) Selectin-carbohydrate interactions and the initiation of the inflammatory response. Annu Rev Biochem 64:113–139

    CAS  PubMed  Google Scholar 

  • Leeuwenberg JF, Asmuth EJ von, Jeunhomme TM, Buurman WA (1990) IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro. J Immunol 145:2110–2114

    CAS  PubMed  Google Scholar 

  • Lesley J, Howes N, Perschl A, Hyman R (1994) Hyaluronan binding function of CD44 is transiently activated on T cells during an in vivo immune response. J Exp Med 180:383–387

    CAS  PubMed  Google Scholar 

  • Ley K, Tedder TF (1995) Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling. J Immunol 155:525–528

    CAS  PubMed  Google Scholar 

  • Liang TW, Chiu HH, Gurney A, Sidle A, Tumas DB, Schow P, Foster J, Klassen T, Dennis K, DeMarco RA, et al (2002) Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. J Immunol 168:1618–1626

    CAS  PubMed  Google Scholar 

  • Liao F, Ali J, Greene T, Muller WA (1997) Soluble domain 1 of platelet-endothelial cell adhesion molecule (PECAM) is sufficient to block transendothelial migration in vitro and in vivo. J Exp Med 185:1349–1357

    Article  CAS  PubMed  Google Scholar 

  • Lobb RR, Hemler ME (1994) The pathophysiologic role of alpha 4 integrins in vivo. J Clin Invest 94:1722–1728

    CAS  PubMed  Google Scholar 

  • Malergue F, Galland F, Martin F, Mansuelle P, Aurrand-Lions M, Naquet P (1998) A novel immunoglobulin superfamily junctional molecule expressed by antigen presenting cells, endothelial cells and platelets. Mol Immunol 35:1111–1119

    Article  CAS  PubMed  Google Scholar 

  • Mamdouh Z, Chen X, Pierini LM, Maxfield FR, Muller WA (2003) Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis. Nature 421:748–753

    Article  CAS  PubMed  Google Scholar 

  • Mantovani A, Bussolino F, Introna M (1997) Cytokine regulation of endothelial cell function: from molecular level to the bedside. Immunol Today 18:231–240

    Google Scholar 

  • Mantovani A, Allavena P, Vecchi A, Sozzani S (1998) Chemokines and chemokine receptors during activation and deactivation of monocytes and dendritic cells and in amplification of Th1 versus Th2 responses. Int J Clin Lab Res 28:77–82

    Article  CAS  PubMed  Google Scholar 

  • Marchesi VT, Gowans JL (1964) Title of article. Proc R Soc Lond [Biol] 159:283–290

    Google Scholar 

  • Martin-Padura I, Lostaglio S, Schneemann M, Williams L, Romano M, Fruscella P, Panzeri C, Stoppacciaro A, Ruco L, Villa A, et al (1998) Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 142:117–127

    CAS  PubMed  Google Scholar 

  • Matsumura T, Wolff K, Petzelbauer P (1997) Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin. J Immunol 158:3408–3416

    CAS  PubMed  Google Scholar 

  • McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF (1989) GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84:92–99

    CAS  PubMed  Google Scholar 

  • Mohamadzadeh M, DeGrendele H, Arizpe H, Estess P, Siegelman M (1998) Proinflammatory stimuli regulate endothelial hyaluronan expression and CD44/HA-dependent primary adhesion. J Clin Invest 101:97–108

    CAS  PubMed  Google Scholar 

  • Moy AB, Shasby SS, Scott BD, Shasby DM (1993) The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells. J Clin Invest 92:1198–1206

    CAS  PubMed  Google Scholar 

  • Moy AB, Engelenhoven J van, Bodmer J, Kamath J, Keese C, Giaever I, Shasby S, Shasby DM (1996) Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces. J Clin Invest 97:1020–1027

    PubMed  Google Scholar 

  • Muller WA (2001) Migration of leukocytes across endothelial junctions: some concepts and controversies. Microcirculation 8:181-193

    Article  CAS  PubMed  Google Scholar 

  • Muller WA (2002) Leukocyte-endothelial cell interactions in the inflammatory response. Lab Invest 82:521–533

    CAS  PubMed  Google Scholar 

  • Muller WA (2003) Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol 24:326–333

    Article  Google Scholar 

  • Muller WA, Weigl SA, Deng X, Phillips DM (1993) PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 178:449–460

    CAS  PubMed  Google Scholar 

  • Naik UP, Ehrlich YH, Kornecki E (1995) Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor. Biochem J 310:155–162

    CAS  PubMed  Google Scholar 

  • Nandi A, Estess P, Siegelman MH (2000) Hyaluronan anchoring and regulation on the surface of vascular endothelial cells is mediated through the functionally active form of CD44. J Biol Chem 275:14939–14948

    Article  CAS  PubMed  Google Scholar 

  • Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G, Golding M, Shima DT, Deutsch U, Vestweber D (2002) VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J 21:4885–4895

    Article  CAS  PubMed  Google Scholar 

  • Neumann FJ, Zohlnhofer D, Fakhoury L, Ott I, Gawaz M, Schomig A (1999) Effect of glycoprotein IIb/IIIa receptor blockade on platelet-leukocyte interaction and surface expression of the leukocyte integrin Mac-1 in acute myocardial infarction. J Am Coll Cardiol 34:1420–1426

    Article  CAS  PubMed  Google Scholar 

  • Newman PJ, Newman DK (2003) Signal transduction pathways mediated by PECAM-1. New roles for an old molecule in platelet and vascular cell biology. Arterioscler Thromb Vasc Biol 10:10

    Google Scholar 

  • Newman PJ, Berndt MC, Gorski J, White GD, Lyman S, Paddock C, Muller WA (1990) PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 247:1219–1222

    CAS  PubMed  Google Scholar 

  • Osawa M, Masuda M, Harada N, Lopes RB, Fujiwara K (1997) Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) in mechanically stimulated vascular endothelial cells. Eur J Cell Biol 72:229–237

    CAS  PubMed  Google Scholar 

  • Ostermann G, Weber KS, Zernecke A, Schroder A, Weber C (2002) JAM-1 is a ligand of the beta2 integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol 14:14

    Google Scholar 

  • Oviedo-Orta E, Hoy T, Evans WH (2000) Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations. Immunology 99:578–590

    Article  CAS  PubMed  Google Scholar 

  • Oviedo-Orta E, Errington RJ, Evans WH (2002) Gap junction intercellular communication during lymphocyte transendothelial migration. Cell Biol Int 26:253–263

    Google Scholar 

  • Ozaki H, Ishii K, Horiuchi H, Arai H, Kawamoto T, Okawa K, Iwamatsu A, Kita T (1999) Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol 163:553–557

    CAS  PubMed  Google Scholar 

  • Ozaki H, Ishii K, Arai H, Horiuchi H, Kawamoto T, Suzuki H, Kita T (2000) Junctional adhesion molecule (JAM) is phosphorylated by protein kinase C upon platelet activation. Biochem Biophys Res Commun 276:873–878

    Article  CAS  PubMed  Google Scholar 

  • Pabst R, Binns RM (1989) Heterogeneity of lymphocyte homing physiology: several mechanisms operate in the control of migration to lymphoid and non-lymphoid organs in vivo. Immunol Rev 108:83–109

    CAS  PubMed  Google Scholar 

  • Palmeri D, Zante A van, Huang CC, Hemmerich S, Rosen SD (2000) Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. J Biol Chem 275:19139–19145

    Article  CAS  PubMed  Google Scholar 

  • Polacek D, Bech F, McKinsey JF, Davies PF (1997) Connexin43 gene expression in the rabbit arterial wall: effects of hypercholesterolemia, balloon injury and their combination. J Vasc Res 34:19–30

    CAS  PubMed  Google Scholar 

  • Preece G, Murphy G, Ager A (1996) Metalloproteinase-mediated regulation of L-selectin levels on leucocytes. J Biol Chem 271:11634–11640

    Article  CAS  PubMed  Google Scholar 

  • Rabiet MJ, Plantier JL, Dejana E (1994) Thrombin-induced endothelial cell dysfunction. Br Med Bull 50:936–945

    CAS  PubMed  Google Scholar 

  • Rabiet MJ, Plantier JL, Rival Y, Genoux Y, Lampugnani MG, Dejana E (1996) Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organization. Arterioscler Thromb Vasc Biol 16:488-496

    PubMed  Google Scholar 

  • Reed KE, Westphale EM, Larson DM, Wang HZ, Veenstra RD, Beyer EC (1993) Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J Clin Invest 91:997–1004

    CAS  PubMed  Google Scholar 

  • Rigby S, Dailey MO (2000) Traffic of L-selectin-negative T cells to sites of inflammation. Eur J Immunol 30:98–107

    Article  CAS  PubMed  Google Scholar 

  • Rijen H van, Kempen MJ van, Analbers LJ, Rook MB, Ginneken AC van, Gros D, Jongsma HJ (1997) Gap junctions in human umbilical cord endothelial cells contain multiple connexins. Am J Physiol 272:C117–C130

    PubMed  Google Scholar 

  • Rijen H van, Kempen MJ van, Postma S, Jongsma HJ (1998) Tumour necrosis factor alpha alters the expression of connexin43, connexin40, and connexin37 in human umbilical vein endothelial cells. Cytokine 10:258–264

    Article  PubMed  Google Scholar 

  • Romer LH, McLean NV, Yan HC, Daise M, Sun J, DeLisser HM (1995) IFN-gamma and TNF-alpha induce redistribution of PECAM-1 (CD31) on human endothelial cells. J Immunol 154:6582–6592

    CAS  PubMed  Google Scholar 

  • Sako D, Chang XJ, Barone KM, Vachino G, White HM, Shaw G, Veldman GM, Bean KM, Ahern TJ, Furie B, et al (1993) Expression cloning of a functional glycoprotein ligand for P-selectin. Cell 75:1179–1186

    CAS  PubMed  Google Scholar 

  • Salmi M, Jalkanen S (1997) How do lymphocytes know where to go: current concepts and enigmas of lymphocyte homing. Adv Immunol 64:139–218

    CAS  PubMed  Google Scholar 

  • Santoso S, Sachs UJ, Kroll H, Linder M, Ruf A, Preissner KT, Chavakis T (2002) The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. J Exp Med 196:679–691

    Article  CAS  PubMed  Google Scholar 

  • Schenkel AR, Mamdouh Z, Chen X, Liebman RM, Muller WA (2002) CD99 plays a major role in the migration of monocytes through endothelial junctions. Nat Immunol 3:143–150

    Article  CAS  Google Scholar 

  • Shaw SK, Bamba PS, Perkins BN, Luscinskas FW (2001) Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium. J Immunol 167:2323–2330

    CAS  PubMed  Google Scholar 

  • Sheldon R, Moy A, Lindsley K, Shasby S, Shasby DM (1993) Role of myosin light-chain phosphorylation in endothelial cell retraction. Am J Physiol 265:L606–L612

    CAS  PubMed  Google Scholar 

  • Shimizu Y, Rose DM, Ginsberg MH (1999) Integrins in the immune system. Adv Immunol 72:325–380

    CAS  PubMed  Google Scholar 

  • Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301–314

    CAS  PubMed  Google Scholar 

  • Stewart M, Thiel M, Hogg N (1995) Leukocyte integrins. Curr Opin Cell Biol 7:690–696

    Article  CAS  PubMed  Google Scholar 

  • Stockinger H, Gadd SJ, Eher R, Majdic O, Schreiber W, Kasinrerk W, Strass B, Schnabl E, Knapp W (1990) Molecular characterization and functional analysis of the leukocyte surface protein CD31. J Immunol 145:3889–3897

    CAS  PubMed  Google Scholar 

  • Tanaka Y, Adams DH, Hubscher S, Hirano H, Siebenlist U, Shaw S (1993) T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1 beta. Nature 361:79–82

    CAS  PubMed  Google Scholar 

  • Timpl R (1989) Structure and biological activity of basement membrane proteins. Eur J Biochem 180:487–502

    CAS  PubMed  Google Scholar 

  • Tinsley JH, Wu MH, Ma W, Taulman AC, Yuan SY (1999) Activated neutrophils induce hyperpermeability and phosphorylation of adherens junction proteins in coronary venular endothelial cells. J Biol Chem 274:24930–24934

    Article  CAS  PubMed  Google Scholar 

  • Tsukita S, Nagafuchi A, Yonemura S (1992) Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions. Curr Opin Cell Biol 4:834–839

    CAS  PubMed  Google Scholar 

  • Vestweber D (2000) Molecular mechanisms that control endothelial cell contacts. J Pathol 190:281–291

    CAS  PubMed  Google Scholar 

  • Watt SM, Gschmeissner SE, Bates PA (1995) PECAM-1: its expression and function as a cell adhesion molecule on hemopoietic and endothelial cells. Leuk Lymphoma 17:229–244

    CAS  PubMed  Google Scholar 

  • Wellicome SM, Thornhill MH, Pitzalis C, Thomas DS, Lanchbury JS, Panayi GS, Haskard DO (1990) A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide. J Immunol 144:2558–2565

    CAS  PubMed  Google Scholar 

  • Wiedle G, Dunon D, Imhof BA (2001) Current concepts in lymphocyte homing and recirculation. Crit Rev Clin Lab Sci 38:1-31

    CAS  PubMed  Google Scholar 

  • Worthylake RA, Burridge K (2001) Leukocyte transendothelial migration: orchestrating the underlying molecular machinery. Curr Opin Cell Biol 13:569–577

    Google Scholar 

  • Zahler S, Hoffmann A, Gloe T, Pohl U (2003) Gap-junctional coupling between neutrophils and endothelial cells: a novel modulator of transendothelial migration. J Leukoc Biol 73:118–126

    Article  CAS  PubMed  Google Scholar 

  • Zanten GH van, Graaf S de, Slootweg PJ, Heijnen HF, Connolly TM, Groot PG de, Sixma JJ (1994) Increased platelet deposition on atherosclerotic coronary arteries. J Clin Invest 93:615–632

    PubMed  Google Scholar 

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Acknowledgements

The authors are especially grateful to Dr. Christiane Ody for critically reviewing the manuscript. This work was supported by Oncosuisse (ocs-01335-02-2003) and the Swiss National Science Foundation (3100A0-100697/1).

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  1. Department of Pathology, University of Geneva, CMU, Rue Michel-Servet 1, 1211, Geneva, Switzerland

    Caroline Johnson-Léger & Beat A. Imhof

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  1. Caroline Johnson-Léger
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  2. Beat A. Imhof
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Correspondence to Beat A. Imhof.

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Johnson-Léger, C., Imhof, B.A. Forging the endothelium during inflammation: pushing at a half-open door?. Cell Tissue Res 314, 93–105 (2003). https://doi.org/10.1007/s00441-003-0775-4

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