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Identification, localization and characterization of the human γ-synuclein gene

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Abstract

We have identified and characterized a new member of the human synuclein gene family, γ-synuclein (SNCG). This gene is composed of five exons, which encode a 127 amino acid protein that is highly homologous to α-synuclein, which is mutated in some Parkinson’s disease families, and to β-synuclein. The γ-synuclein gene is localized to chromosome 10q23 and is principally expressed in the brain, particularly in the substantia nigra. We have determined its genomic sequence, and established conditions for sequence analysis of each of the exons. The γ-synuclein gene, also known as BCSG1, was recently found to be overexpressed in advanced infiltrating carcinoma of the breast. Our survey of the EST database indicated that it might also be overexpressed in an ovarian tumor.

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Authors and Affiliations

  1. Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, 49/4A66, Bethesda, MD 20892, USA Tel.: +1-301-402-2119, Fax: +1-301-402-2170, , , , , , US

    Christian Lavedan, Elisabeth Leroy, Anindya Dehejia, Stephanie Buchholtz, Robert L. Nussbaum & M. H. Polymeropoulos

  2. Laboratory of Gene Transfer, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA, , , , , , US

    Amalia Dutra

Authors
  1. Christian Lavedan
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  2. Elisabeth Leroy
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  3. Anindya Dehejia
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  4. Stephanie Buchholtz
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  5. Amalia Dutra
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  6. Robert L. Nussbaum
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  7. M. H. Polymeropoulos
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Received: 6 February 1998 / Accepted: 8 April 1998

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Lavedan, C., Leroy, E., Dehejia, A. et al. Identification, localization and characterization of the human γ-synuclein gene. Hum Genet 103, 106–112 (1998). https://doi.org/10.1007/s004390050792

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  • DOI: https://doi.org/10.1007/s004390050792

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