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MTHFR association with arteriosclerotic vascular disease?

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Abstract

Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.

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Authors and Affiliations

  1. Medical and Community Genetics, Imperial College School of Medicine, Kennedy Galton Centre, Level 8 V, Northwick Park and St. Mark’s NHS Trust, Watford Road, Harrow HA1 3UJ, UK Fax: +44 181 869 3167, , , , , , GB

    Olivia Fletcher & A. M. Kessling

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  1. Olivia Fletcher
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  2. A. M. Kessling
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Received: 21 October 1997 / Accepted: 1 April 1998

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Fletcher, O., Kessling, A. MTHFR association with arteriosclerotic vascular disease?. Hum Genet 103, 11–21 (1998). https://doi.org/10.1007/s004390050776

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  • DOI: https://doi.org/10.1007/s004390050776

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