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Association between the PI*M3 allele of α1-antitrypsin and Alzheimer’s disease? A preliminary report

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Abstract

The deposition of βA4-amyloid in senile plaques in the brain and small cerebral vessels is one of the pathological hallmarks of Alzheimer’s disease (AD). Serine protease inhibitors (serpins) such as α1-antitrypsin and α1-antichymotrypsin have been found to be associated with β-amyloid deposits; interest in their role in the pathogenesis of AD has therefore recently increased. We have analyzed α1-antitrypsin phenotypes in a sample of 29 Polish patients with probable Alzheimer’s disease. We have found an increased frequency of the PI*M3 allele (0.1897) in patients in comparison with the general population control (0.0563).

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Authors and Affiliations

  1. Institute of Human Genetics, Polish Academy of Sciences, 32 Strzeszynska, 60-479 Poznan, Poland Fax: +48-61-233-235, , , , , , PL

    A. Kowalska

  2. Department of Human Biology, University of Bremen, Bremen, Germany, , , , , , DE

    Heidi Danker-Hopfe & Hubert Walter

  3. Department of Neurology, Medical Academy of Poznan, Poznan, Poland, , , , , , PL

    Mieczyslaw Wender & Jolanta Florczak

Authors
  1. A. Kowalska
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  2. Heidi Danker-Hopfe
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  3. Mieczyslaw Wender
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  4. Jolanta Florczak
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  5. Hubert Walter
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Received: 8 May 1996 / Revised 28 June 1996

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Kowalska, A., Danker-Hopfe, H., Wender, M. et al. Association between the PI*M3 allele of α1-antitrypsin and Alzheimer’s disease? A preliminary report. Hum Genet 98, 744–746 (1996). https://doi.org/10.1007/s004390050297

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  • DOI: https://doi.org/10.1007/s004390050297

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