Abstract
Atrial fibrillation (AF) is the most common arrhythmia in the clinical setting and an independent risk factor for stroke. Approximately 10 million Chinese people are affected by AF, but the genetic basis is largely unknown. A recent genome-wide association study in Iceland identified association between SNP rs2200733 on 4q25 and AF; however, many independent replication studies are essential to unequivocally validate this association. To assess the association between rs2200733 and AF as well as that between rs2200733 and ischemic stroke in a mainland Chinese Han population, we carried out case–control association studies with 383 AF patients versus 851 non-AF controls and 811 ischemic stroke patients versus 688 non-stroke controls. Highly significant association was detected between rs2200733 and AF in a Chinese Han population (allelic P = 3.7 × 10−11 with OR = 1.81; genotypic P = 4.1 × 10−12 with a dominant model). When the AF cases were divided into lone AF (32.6%) and other types of AF (67.4%), significantly stronger association was found with lone AF (OR = 2.40, P = 1.3 × 10−9 compared to OR = 1.59, P = 6.2 × 10−7 for other types of AF; P = 0.02 for two ORs). No significant association was found between rs2200733 and ischemic stroke. Our results suggest that SNP rs2200733 confers a highly significant risk of AF, but not ischemic stroke, in a more representative Chinese Han population in the mainland China.
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Acknowledgments
We thank all patients and normal control individuals for their participation of this study. We thank Drs. Dingfeng Su and Baofeng Yang for their help. This work was supported by the China National Basic Research Program (973 program 2007CB512000 and 2009CB521901), China National 863 Scientific Program (2006AA02Z476) and National Natural Science Foundation of China (30670857; 30800457). This study was approved by the Institutional Review Board of College of Life Science and Technology, Huazhong University of Science and Technology.
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L. Shi, C. Li, C. Wang, Y. Xia, and G. Wu contributed equally to this work.
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Shi, L., Li, C., Wang, C. et al. Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Hum Genet 126, 843–849 (2009). https://doi.org/10.1007/s00439-009-0737-3
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DOI: https://doi.org/10.1007/s00439-009-0737-3