Abstract
Chen et al. found that the CA haplotype of protein C -1654C/T and -1641G/A was associated with increased risk of death and organ dysfunction in Chinese Han patients with severe sepsis (Hum Genet 123:281–287, 2008). We similarly tested for association of the C allele of protein C 673 T/C (rs2069912) (linkage disequilibrium with the CA haplotype, D′ = 100%) in a cohort of 100 North American East Asians with severe sepsis. The C allele was associated with increased mortality and organ dysfunction, consistent with Chen et al.
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References
American College of Chest Physicians (ACCP)/Society of Critical Care Medicine Consensus Conference (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864–874
Chen QX, Wu SJ, Wang HH, Lv C, Cheng BL, Xie GH, Fang XM (2008) Protein C -1641A/-1654C haplotype is associated with organ dysfunction and the fatal outcome of severe sepsis in Chinese Han population. Hum Genet 123:281–287
Walley KR, Russell JA (2007) Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. Crit Care Med 35:12–17
Conflict of interest and financial disclosure
Dr. Russell reports serving as an officer and holding stock in Sirius Genomics Incorporated, which has submitted a patent owned by the University of British Columbia and licensed to Sirius Genomics, that is related to the genetics of protein C. Dr. Russell reports being an inventor on this patent. Dr. Russell reports receiving consulting fees from Ferring, which manufactures vasopressin. Dr. Russell reports receiving grant support from Sirius Genomics, Novartis, and Eli Lilly.
Dr. Walley reports serving as an officer and holding stock in Sirius Genomics Incorporated, which has submitted a patent owned by the University of British Columbia and licensed to Sirius Genomics, that is related to the genetics of protein C. Dr. Walley reports being an inventor on this patent. Dr. Walley reports receiving grant support from Sirius Genomics.
Mr. Wellman reports serving as a Research Scientist and holding options at Sirius Genomics Incorporated, which has submitted a patent University owned by the of British Columbia and licensed to Sirius Genomics, that is related to the genetics of protein C.
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Support: Sirius Genomics Inc., Canadian Institutes of Health Research. Keith R. Walley is a Michael Smith Foundation for Health Research Distinguished Scholar.
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Russell, J.A., Wellman, H. & Walley, K.R. Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry. Hum Genet 123, 661–663 (2008). https://doi.org/10.1007/s00439-008-0509-5
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DOI: https://doi.org/10.1007/s00439-008-0509-5