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Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection

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Abstract

Asthma is a complex trait which is influenced by environmental and genetic factors. In a recent genome-wide association study on asthma in European subjects, novel associations were reported between 17q21 single nucleotide polymorphisms (SNPs) and childhood asthma. We performed an association study with the ten SNPs that showed the strongest association in a French-Canadian asthmatic familial collection. Family-based association tests revealed significant associations for eight SNPs (0.005 < P < 0.017) and for two haplotypes (P = 0.0004 and 0.002), confirming the 17q21 as an asthma locus.

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Acknowledgments

We express our gratitude to all probands and their family for participating in the study. We thank S. Claveau for his help in genotyping. A.-M. Madore is supported by the Canadian Institutes of Health Research (CIHR). K. Tremblay is supported by a grant from the Laval University Foundation. T.J. Hudson was supported by a Clinician-Scientist Award in Translational Research from the Burroughs Wellcome Fund. C. Laprise is the chairholder of the Canada Research Chair for genetic determinants in asthma (http://www.chairs.gc.ca) and the director of the Genetics & Genomics Thematic Unit of the Respiratory Health Network of the Fonds de la Recherche en Santé du Québec (FRSQ).

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Authors and Affiliations

  1. Department of Medicine, Laval University, Laval, QC, Canada

    Anne-Marie Madore & Karine Tremblay

  2. University of Montreal Community Genomics Medicine Centre, Chicoutimi Hospital, Saguenay, QC, Canada

    Anne-Marie Madore, Karine Tremblay & Catherine Laprise

  3. Department of Fundamental Sciences, Université du Québec à Chicoutimi, Saguenay, QC, Canada

    Anne-Marie Madore, Karine Tremblay & Catherine Laprise

  4. Ontario Institute for Cancer Research, Toronto, ON, Canada

    Thomas J. Hudson

  5. Université du Québec à Chicoutimi, 555 blv de l’Université, G7H 2B1, Chicoutimi, QC, Canada

    Catherine Laprise

Authors
  1. Anne-Marie Madore
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  2. Karine Tremblay
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  3. Thomas J. Hudson
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  4. Catherine Laprise
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Corresponding author

Correspondence to Catherine Laprise.

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Madore, AM., Tremblay, K., Hudson, T.J. et al. Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection. Hum Genet 123, 93–95 (2008). https://doi.org/10.1007/s00439-007-0444-x

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  • DOI: https://doi.org/10.1007/s00439-007-0444-x

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