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Interaction between the UCP2–866G/A, mtDNA 10398G/A and PGC1α p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population

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An Erratum to this article was published on 08 January 2008

Abstract

In the recent past, we have observed a possible role of 10398A and 16189C mtDNA and PGC1α p.Thr394Thr (rs2970847) and p.Gly482Ser (rs8192673) variant genotypes providing susceptibility/protection against type 2 diabetes mellitus (T2DM) in two North Indian population groups. These initial observations encouraged us to look at the candidate genes in combination with –866G/A (rs659366) polymorphism in uncoupling protein 2 (UCP2) in a single study of a relatively large sample size, constituted of both the cohorts, to unravel an interesting outcome of an additive interaction in-between the studied genes. In a total of 1,686 individuals (762 cases and 924 controls) belonging to Indo-European linguistic group from North India, a comparison of risk genotype combinations of: UCP2–866GG, mtDNA 10398A and PGC1α p.Thr394Thr or p.Gly482Ser against the protective genotypes: UCP2–866XA, mtDNA 10398G and PGC1α p.Thr394Thr (nominal P value = 1.75 × 10−14, Odds ratio, OR = 5.29, 3.40–8.22 at 95% CI) or PGC1α p.Gly482Ser (nominal p value = 4.42 × 10−24, OR = 8.59, 5.53–13.35 at 95% CI), showed a highly significant difference and increased ORs. In a complex disease, it is always encouraging to find an additive interaction of multiple small effects of the studied candidate gene variations.

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Acknowledgment

The financial assistance to SS and AK as SRF (CSIR, India) and ER as JRF (UGC, India) is acknowledged. The authors acknowledge K. Matharoo, N. K. Randhawa and R. Bedi for providing their help in sample collection. The authors also acknowledge the grant given to the National Centre of Applied Human Genetics by UGC, India, to carry out this study.

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Authors and Affiliations

  1. National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    E. Rai, S. Sharma, A. Koul, A. K. Bhat & R. N. K. Bamezai

  2. Department of Human Genetics, Guru Nanak Dev University, Amritsar, India

    E. Rai, S. Sharma & A. J. S. Bhanwer

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  1. E. Rai
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  2. S. Sharma
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  3. A. Koul
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  4. A. K. Bhat
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  5. A. J. S. Bhanwer
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  6. R. N. K. Bamezai
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Correspondence to R. N. K. Bamezai.

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An erratum to this article is available at http://dx.doi.org/10.1007/s00439-007-0462-8.

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Rai, E., Sharma, S., Koul, A. et al. Interaction between the UCP2–866G/A, mtDNA 10398G/A and PGC1α p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population. Hum Genet 122, 535–540 (2007). https://doi.org/10.1007/s00439-007-0421-4

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  • DOI: https://doi.org/10.1007/s00439-007-0421-4

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