Abstract
To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (ORAA = 1.4, 95% CI = 1.1–1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.
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Acknowledgements
This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, with Public Health Service (PHS) contracts N01-PC-65064, N01-PC-67008, N01-PC-67009, N01-PC-67010, and N02-PC-71105.
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Wang, S.S., Cozen, W., Severson, R.K. et al. Cyclin D1 splice variant and risk for non-Hodgkin lymphoma. Hum Genet 120, 297–300 (2006). https://doi.org/10.1007/s00439-006-0212-3
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DOI: https://doi.org/10.1007/s00439-006-0212-3