Abstract
Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.
References
Dhanda RK, Smith WM, Scott CB, Eng C, Vijg J (1998) A simple system for automated two-dimensional electrophoresis: applications to genetic testing. Genet Test 2:67–70
Hardman RA, Afshari CA, Barrett JC (2001) Involvement of mammalian MLH1 in the apoptotic response to peroxide-induced oxidative stress. Cancer Res 61:1392–1397
Pang Q, Prolla TA, Liskay RM (1997) Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations. Mol Cell Biol 17:4465–4473
Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A, Liskay RM (1998) Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat Genet 18:276–279
Shcherbakova PV, Kunkel TA (1999) Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations. Mol Cell Biol 19:3177–3183
Wei Q (1998) Effect of aging on DNA repair and skin carcinogenesis: a minireview of population-based studies. J Investig Dermatol Symp Proc 3:19–22
Acknowledgements
This work was supported by grants from the Korean Research Foundation for Health Science, from the National Research Laboratory Programme for Rheumatic Disease, and from the Aging and Apoptosis Research Center of KOSEF, Korea Ministry of Science and Technology.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kim, D.J., Yi, S.M., Lee, S.Y. et al. Association between the MLH1 gene and longevity. Hum Genet 119, 353–354 (2006). https://doi.org/10.1007/s00439-006-0148-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00439-006-0148-7