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Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR

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Abstract

Psoriasis is a complex inflammatory disease of the skin affecting 1–2% of the Caucasian population. Associations with alleles from the HLA class I region (now known as PSORS1), particularly HLA-Cw*0602, were described over 20 years ago. However, extensive linkage disequilibrium (LD) within this region has made it difficult to identify the true susceptibility allele from this region. A variety of genes and regions from a 238-kb interval extending from HLA-B to corneodesmosin (CDSN) have been proposed to harbor PSORS1. In order to identify the minimum block of LD in the MHC class I region associated with psoriasis we performed a comprehensive case/control and family-based association study on 242 Northern European psoriasis families and two separate European control populations. High resolution HLA typing of HLA-A, -B and -C alleles was performed, in addition to the genotyping of 18 polymorphic microsatellites and 36 SNPs from a 772-kb segment of the HLA class I region harboring the previously described interval. This corresponded on average to one SNP every 7 kb in the candidate 238 kb region. With all tests, the association was the strongest with single markers and haplotypes from a block of LD harboring HLA-C and SNP n.9. Logistic regression analyses indicated that association seen with candidate genes from the interval such as CDSN and HCR was entirely dependent on association with HLA-Cw*0602 and SNP n.9-G alleles. The previously reported association with CDSN and HCR was observed to be due to the existence of the associated alleles lying on the most commonly over-transmitted haplotype. Rare over-transmitted haplotypes also harbored HLA-Cw*12 alleles. HLA-Cw*12 family members are closely related to HLA Cw*0602, sharing identical sequences in their alpha-2 domains, peptide-binding pockets A, D and E and all 3′ introns. The introduction of a potential binding site for the RUNX/AML family of transcription factors in intron 7, is also specific to these HLA-C alleles. These variants need to be investigated further for their role as PSORS1.

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Acknowledgements

We thank Melodie Young, Christina Zhao, Margaret Wright, Rebecca Cochran, Nahid Attar, Shari Lander and Laura Kuykendahl for family collection and technical help. We are also indebted to the many physicians, physician assistants and families with psoriasis for family identification and blood collection. We thank Mary Akin for help in preparation of this manuscript. This work was supported in part by funding from National Psoriasis Foundation (NPF) to AMB and AM, and NIH grants AR44577, AR04904901 (AMB) and HG01720 (PYK).

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  1. Marcelo A. Fernandez-Vina

    Present address: Department of Laboratory Medicine, The University of Texas M.D. Anderson, Cancer Center, Houston, TX, USA

Authors and Affiliations

  1. Department of Genetics, Washington University School of Medicine, Box 8232, 4566 Scott Avenue, St. Louis, Missouri, 63110, USA

    Cynthia Helms, Nancy L. Saccone, Li Cao, Jil A. Wright. Daw, Brandon Pierce & Anne M. Bowcock

  2. Laboratory of Statistical Genetics, The Rockeffer University, New York, USA

    Derek Gordon & Jurg Ott

  3. Department of Psychiatry, Washington University School of Medicine, St. Louis, USA

    Nancy L. Saccone & John Rice

  4. Oncology Department, Georgetown University School of Medicine, Washington, DC, USA

    Kai Cao & Marcelo A. Fernandez-Vina

  5. Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, USA

    Tony M. Hsu, Patricia Taillon-Miller, Shenghui Duan, Pui-Yan Kwok & Anne M. Bowcock

  6. Department of Internal Medicine, Division of Dermatology, Baylor University Medical Center, Dallas, USA

    Alan Menter

  7. Department of Laboratory Medicine, The University of Texas M.D. Anderson, Cancer Center, Houston, TX, USA

    Kai Cao

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Helms, C., Saccone, N.L., Cao, L. et al. Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR. Hum Genet 118, 466–476 (2005). https://doi.org/10.1007/s00439-005-0048-2

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