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A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers

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Abstract.

Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with putative autoimmune aetiology and complex genetic background. Here, we report the results of a genome screen for linkage disequilibrium (LD) by using 6000 microsatellite markers in 198 HLA-DRB1*15-positive MS patients and 198 unrelated controls (pooled DNA); 4666 analysed markers could be included in the resulting association map, from which 87 revealed significant differences between MS cases and controls.

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Authors and Affiliations

  1. Department of Molecular Human Genetics, Ruhr-University, Universitätsstrasse 150, 44780 Bochum, Germany, Germany

    Rene Goedde, Stefan Boehringer, Bianca Miterski & Joerg T. Epplen

  2. Department of Neurology, Kliniken Bergmannsheil, Ruhr-University, Bochum, Germany

    Eckhart Sindern

  3. Department of Neurology, Knappschaftskrankenhaus, Ruhr-University, Bochum, Germany

    Michael Haupts

  4. Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany

    Sebastian Schimrigk

  5. University of Cambridge, Neurology Unit, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK

    Stephen Sawcer & Alastair Compston

Authors
  1. Rene Goedde
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  2. Stephen Sawcer
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  3. Stefan Boehringer
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  4. Bianca Miterski
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  5. Eckhart Sindern
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  6. Michael Haupts
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  7. Sebastian Schimrigk
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  8. Alastair Compston
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  9. Joerg T. Epplen
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Goedde, R., Sawcer, S., Boehringer, S. et al. A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers. Hum Genet 111, 270–277 (2002). https://doi.org/10.1007/s00439-002-0801-8

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  • DOI: https://doi.org/10.1007/s00439-002-0801-8

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