Abstract
Interleukin-5 (IL-5) production, eosinophilia, and IgA responses of BALB/c mice infected with Trichinella spiralis were measured in the peritoneal cavity and intestinal mucosa. Ketotifen, an anti-allergic compound, was used to control the inflammatory response. IgA responses differed against adult and muscle stages of the parasite and between the intestine and the peritoneal cavity. IL-5 and eosinophil production also differed between the intestine and the peritoneal cavity. The occurrence of parasite-specific IgA antibodies in the peritoneal cavity may reflect the migration of cells from the lamina propria. Following ketotifen treatment there was a reduction in the IL-5, eosinophilic, and IgA responses; these responses affected both the size of worms and the number of worms.
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Received: 14 December 1999 / Accepted: 6 January 2000
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Doligalska, M., Laskowska, M. Inhibition of the protective IgA response by ketotifen is related to the inflammatory reaction in the peritoneal cavity and intestinal mucosa of BALB/c mice infected with Trichinella spiralis . Parasitol Res 86, 480–485 (2000). https://doi.org/10.1007/s004360050697
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DOI: https://doi.org/10.1007/s004360050697