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Molecular cloning and expression of an anti-idiotype antibody mimicking a protective oligosaccharide of the parasite Schistosoma mansoni

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Abstract

Genes encoding the heavy and light chains of an anti-idiotype antibody (AB2) mimicking a protective oligosaccharide of Schistosoma mansoni were cloned and expressed as a single-chain Fv fragment. The expression in a functional state was tested using the AB1. A specific binding between sFv and AB1 was observed. Immunization with the recombinant AB2 indicates its capacity to elicit anti-S. mansoni antibodies.

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Authors and Affiliations

  1. INSERM U167 Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, F-59019 Lille, France Tel.: (33) 20.87.78.09; Fax: (33) 20.87.78.88; e-mail: karine.petitprez@pasteur-lille.fr, , , , , , FR

    Karine Petitprez, Jean-Marie Grzych, Christine Pierrot, Claude Godin, André Capron & Jamal Khalife

Authors
  1. Karine Petitprez
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  2. Jean-Marie Grzych
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  3. Christine Pierrot
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  4. Claude Godin
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  5. André Capron
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  6. Jamal Khalife
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Received: 28 April 1997 / Accepted: 24 June 1997

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Petitprez, K., Grzych, JM., Pierrot, C. et al. Molecular cloning and expression of an anti-idiotype antibody mimicking a protective oligosaccharide of the parasite Schistosoma mansoni . Parasitol Res 84, 38–40 (1997). https://doi.org/10.1007/s004360050353

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  • DOI: https://doi.org/10.1007/s004360050353

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