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Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro

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Abstract

The effect of doxycycline, obtained from human volunteers administered doxycycline, on the minimum inhibitory concentration (MIC) of atovaquone was determined against the K1 and FC27 isolates of Plasmodium falciparum in vitro. Doxycycline concentrations ranging from 0.10-1.18 μg/ml added to atovaquone produced MIC ratios [atovaquone + doxycycline/atovaquone alone] ranging from 0.38 to 0.70. These results suggest that the antimalarial activity of atovaquone is potentiated by doxycycline. Additionally, these drugs may be rational partners for the treatment and prophylaxis of falciparum malaria.

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Authors and Affiliations

  1. Army Malaria Research Unit, Liverpool Military Area, NSW 2174, Australia, , , , , , AU

    Anthony E. T. Yeo, Michael D. Edstein & Karl H. Rieckmann

  2. US Army Medical Research Unit Kenya, Unit 64109, Box 401, APO AE 09831-4109, USA, , , , , , KE

    G. Dennis Shanks

Authors
  1. Anthony E. T. Yeo
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  2. Michael D. Edstein
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  3. G. Dennis Shanks
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  4. Karl H. Rieckmann
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Received: 4 October 1996 / Accepted: 29 November 1996

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Yeo, A., Edstein, M., Shanks, G. et al. Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro. Parasitol Res 83, 489–491 (1997). https://doi.org/10.1007/s004360050285

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  • DOI: https://doi.org/10.1007/s004360050285

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