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Acute phase proteins increase with sarcoptic mange status and severity in Iberian ibex (Capra pyrenaica, Schinz 1838)

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Abstract

Sarcoptic mange is a contagious skin disease caused by Sarcoptes scabiei, affecting both domestic and wild mammals, including the Iberian ibex (Capra pyrenaica), a medium-sized mountain ungulate almost endemic to the Iberian Peninsula. Acute phase proteins (APPs) could be an indicator of sarcoptic mange disease and severity in Iberian ibex. Serum samples from 131 healthy and sarcoptic mange-affected Iberian ibexes were collected from 2005 to 2012 in Sierra Nevada Natural Space in southern Spain. Serum alpha-1-acid glycoprotein (AGP), serum amyloid A (SAA) and haptoglobin (Hp) concentrations were quantified, and statistically significant differences according to sarcoptic mange disease and severity were assessed. Both AGP and SAA were significantly higher in the sarcoptic mange-affected ibexes than in the healthy ones as well as in the severely affected ibexes as compared to those with less than 50 % of the body surface affected. For the first time, changes in APP are reported in relation to sarcoptic mange in Iberian ibex. It is also reported for the first time that the intensity of APP increase depends on the severity of sarcoptic mange, which could be related with the pathological secondary amyloidosis, leading to organ dysfunction in severely mange-affected animals. Species and population differences in the increase of APP in response to sarcoptic mange could indicate individual and population differences in the immune capability of each population to deal with mange, population prevalence and mortality being the last indicators of such sensitivity.

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Acknowledgments

The authors are grateful to the institution and authorities from the Parque Nacional de Sierra Nevada and the Consejería de Medio Ambiente y Ordenación del Territorio of the Junta de Andalucía for the support given to this study. Ibex capture and sample collection would not have been possible without José López, Apolo Sánchez, Isidro Puga, Elías Martínez, Manuela Fernández, Francisco Casado and Antonio Rodríguez, to whom the authors are deeply indebted. Thanks are also due to Rafaela Cuenca and Ester Bach, from the Servei d’Hematologia Clínica Veterinària of the Universitat Autònoma de Barcelona. This study was funded by the Ministerio de Economía y Competitividad of the Spanish Government research project, CGL2012-40043-C02-02. The authors’ research activities are partially funded by the Plan Andaluz de Investigación (RNM-118 group).

Conflict of interest

The authors declare that they have no competing interests.

Compliance with ethical standards

This study accomplished with all Andalusian, Spanish and European legal requirements and guidelines regarding animal welfare, was approved by the Ethics on Animal Welfare Committee of the Universidad de Jaén and authorized by the Dirección General de Producción Agrícola y Ganadera of the Consejería de Agricultura, Pesca y Medio Ambiente of the Junta de Andalucía.

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Authors and Affiliations

  1. Servei d’Ecopatologia de Fauna Salvatge (SEFaS), Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona (UAB), Bellaterra, Barcelona, E-08193, Spain

    Arián Ráez-Bravo & Jorge Ramón López-Olvera

  2. Espacio Natural Sierra Nevada, Carretera Antigua de Sierra Nevada, Km 7, E-18071, Pinos Genil, Granada, Spain

    José Enrique Granados & Francisco Javier Cano-Manuel

  3. Departmento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad de Murcia, Espinardo, E-30100, Murcia, Spain

    José Joaquín Cerón

  4. Agencia de Medio Ambiente y Agua, Isla de la Cartuja, E-41092, Sevilla, Spain

    Paulino Fandos

  5. Departamento de Biología Animal, Biología Vegetal y Ecología, Universidad de Jaén, Campus Las Lagunillas, s.n., E-23071, Jaén, Spain

    Jesús María Pérez & José Espinosa

  6. Estación Biológica de Doñana (CSIC), Av. Américo Vespucio, s.n., E-41092, Sevilla, Spain

    Ramón Casimiro Soriguer

Authors
  1. Arián Ráez-Bravo
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  2. José Enrique Granados
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  3. José Joaquín Cerón
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  4. Francisco Javier Cano-Manuel
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  5. Paulino Fandos
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  6. Jesús María Pérez
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  7. José Espinosa
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  8. Ramón Casimiro Soriguer
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  9. Jorge Ramón López-Olvera
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Corresponding author

Correspondence to Jorge Ramón López-Olvera.

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Ráez-Bravo, A., Granados, J.E., Cerón, J.J. et al. Acute phase proteins increase with sarcoptic mange status and severity in Iberian ibex (Capra pyrenaica, Schinz 1838). Parasitol Res 114, 4005–4010 (2015). https://doi.org/10.1007/s00436-015-4628-3

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