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Efficacy of extracts of immature mango on ovine gastrointestinal nematodes

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Abstract

The principal health problem in small ruminants is helminthiasis and the rapid development of nematode resistance to anthelminthics has limited the success of control in several countries, stimulating the search for alternatives. In this study, extracts of immature fruits of the mango Mangifera indica L. var Ubá were evaluated for inhibition of larval development and fecal egg count reduction in sheep naturally infected with gastrointestinal nematodes. In the phytochemical analyses, tannins and flavonoids were the metabolites identified. Aqueous extracts of immature fruits at 100 mg ml−1 showed 100 % inhibition of larval development. The LC90 of the extract was 35.9 mg ml−1 and the in vivo anthelminthic efficacy at 0.740 g kg−1 (BW, orally) was 53 %. The identification of larvae showed that 99.8 % were Haemonchus spp. In vitro and in vivo results indicate that this fruit could assist ovine nematode control.

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Abbreviations

BW:

Body weight

DM:

Dry matter

EHI:

Egg-hatching inhibition

FEC:

Fecal egg count

GNIs:

Gastrointestinal nematodiasis

LC:

Lethal concentration

LD:

Lethal dose

LDI:

Larval development inhibition

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Acknowledgments

Financial support of the Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG), Banco do Nordeste and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-Brazil is acknowledged. The authors are also grateful to the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil) and PRPq/UFMG.

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Authors and Affiliations

  1. Instituto de Ciências Agrárias, Universidade Federal de Minas Gerais, Av Universitária 1000, Bairro Universitário, Montes Claros, MG, 39400-006, Brazil

    Patrícia S. Nery, Flávia A. Nogueira, Neide J. F. Oliveira, Ernane R. Martins & Eduardo R. Duarte

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  1. Patrícia S. Nery
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  2. Flávia A. Nogueira
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  3. Neide J. F. Oliveira
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  4. Ernane R. Martins
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  5. Eduardo R. Duarte
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Correspondence to Eduardo R. Duarte.

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Nery, P.S., Nogueira, F.A., Oliveira, N.J.F. et al. Efficacy of extracts of immature mango on ovine gastrointestinal nematodes. Parasitol Res 111, 2467–2471 (2012). https://doi.org/10.1007/s00436-012-3017-4

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  • DOI: https://doi.org/10.1007/s00436-012-3017-4

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