Abstract
Artesuante (AS) is a good chemoprophylactic drug for preventing against schistosome infection, but Hua et al. recently reported that the sensitivity of AS against Schistosoma japonicum decreased after 10 years of use in China. There are at least three problems, to our knowledge, making the finding suspicious or inconclusive in that report. In consideration of it as the first report about the emergence of potential artemisinin derivative-resistant S. japonicum to date and the possible severe influences of the emergence of AS-resistant S. japonicum on the future choice of chemoprophylactic drugs for preventing against S. japonicum infections in China, we write this comment and call for some more rigorous and convincing trials to confirm this finding further.
References
Hua HY, Liang YS, Zhang Y, Wei JF, Guo HX (2010) The sensitivity of artesunate against Schistosoma japonicum decreased after 10 years of use in China. Parasitol Res 107:873–878
Inyang-Etoh PC, Ejezie GC, Useh MF, Inyang-Etoh EC (2009) Efficacy of a combination of praziquantel and artesunate in the treatment of urinary schistosomiasis in Nigeria. Trans R Soc Trop Med Hyg 103:38–44
Xia CS, Zhao XY, Liu YF, Jiang ZH, Li NP (2000) Observation of the efficacy on schistosomiasis prevention with artesunate and praziquantel. J Prev Med Chin PLA 18:120–121 (in Chinese)
Xiao SH (2005) Development of antischistosomal drugs in China, with particular consideration to praziquantel and the artemisinins. Acta Trop 96:153–167
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Liu, R., Dong, HF. & Jiang, MS. The sensitivity of artesunate against Schistosoma japonicum decreased after 10 years of use in China?. Parasitol Res 110, 1563–1564 (2012). https://doi.org/10.1007/s00436-011-2641-8
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DOI: https://doi.org/10.1007/s00436-011-2641-8